Tryphonas L, Nielsen N O
Can J Comp Med. 1970 Jul;34(3):181-90.
To produce arylmercurial poisoning, phenylmercuric chloride (PMC) was administered daily to 30 healthy five week-old piglets for periods of up to 90 days. The dosage used ranged from 0.19 to 4.56 mg of mercury (Hg)/kg. Levels exceeding 2.28 mg Hg/kg daily were moderately toxic. The disease occurring in this intoxication resulted from injury to the kidneys and large intestine. Fetid diarrhea and failure to gain weight were consistent clinical signs. The primary gross lesions were necrotic typhlitis and colitis, and nephrosis. Degeneration and necrosis were found in affected organs. Regeneration was prominent in the proximal convoluted tubules. The pathology of this disease was similar to that described for mercuric chloride poisoning in other species and, presumably, reflected the ease with which PMC was metabolized to release mercuric ion.Tissue analysis for mercury suggested that only certain target organs, such as kidney and colon, accumulated significantly high levels of mercury. This, presumably, resulted from rapid metabolism of the compound and excretion of mercuric ion in the kidney and colon. The net effect was to spare other tissues, and to injure the excretory organs when the dose level was sufficiently high.
为引发芳基汞中毒，对30只健康的5周龄仔猪每日给予苯基氯化汞（PMC），持续时间长达90天。使用的剂量范围为0.19至4.56毫克汞（Hg）/千克。每日超过2.28毫克汞/千克的剂量具有中等毒性。这种中毒所引发的疾病是由肾脏和大肠受损导致的。恶臭腹泻和体重不增是一致的临床症状。主要的大体病变为坏死性盲肠炎和结肠炎以及肾病。在受影响的器官中发现了变性和坏死。近端曲管中的再生现象明显。这种疾病的病理学与其他物种中氯化汞中毒所描述的相似，并且大概反映了PMC代谢释放汞离子的容易程度。对汞的组织分析表明，只有某些靶器官，如肾脏和结肠，积累了显著高水平的汞。这大概是由于该化合物的快速代谢以及汞离子在肾脏和结肠中的排泄所致。最终结果是使其他组织免受影响，而当剂量水平足够高时会损伤排泄器官。
