Heyes H, Mohr W, Theiss W
Thromb Haemost. 1979 Feb 15;40(3):499-511.
In rats a single injection of endotoxin followed by an infusion of normal saline induced the generalized Shwartzman reaction. The presence of disseminated intravascular coagulation (DIC) was demonstrated by measuring plasma fibrinogen, platelet counts, schistocytes, plasma haemoglobin, fibrin(ogen) degradation products, and fibrin thrombi in the glomerular capillaries, 125I-fibrinogen was given after triggering DIC in order to examine the fibrinogen turnover in plasma and the kinetics of fibrin deposition and removal in kidney, liver, and spleen. 125I-fibrinogen turnover was found to be highly accelerated. Early deposition and removal were observed in the kidneys, while a later peak with a more delayed fall of radioactivity was noted in liver and spleen. On histological examination fibrin could be seen only in the glomerular capillaries and only in the early phase of DIC. In radioautographs radioactive material was localized in the glomerular capillaries, the Kupffer' cells of the liver, and in the perifollicular macrophages of the spleen. Comparing the results obtained by scintillation counting to those obtained by light microscopy it can be assumed that radioactivity in kidneys is correlated to fibrin deposition in glomerular capillaries and to an accumulation on fibrin(ogen) degradation products in liver and spleen.
在大鼠中，单次注射内毒素后输注生理盐水可诱发全身性施瓦茨曼反应。通过测量血浆纤维蛋白原、血小板计数、裂体细胞、血浆血红蛋白、纤维蛋白（原）降解产物以及肾小球毛细血管中的纤维蛋白血栓，证实了弥散性血管内凝血（DIC）的存在。在引发DIC后给予125I-纤维蛋白原，以研究血浆中纤维蛋白原的周转率以及肾脏、肝脏和脾脏中纤维蛋白沉积和清除的动力学。发现125I-纤维蛋白原的周转率高度加快。在肾脏中观察到早期沉积和清除，而在肝脏和脾脏中则观察到放射性下降更延迟的后期峰值。组织学检查显示，仅在DIC的早期阶段，在肾小球毛细血管中可见纤维蛋白。在放射自显影片中，放射性物质定位于肾小球毛细血管、肝脏的库普弗细胞和脾脏的滤泡周围巨噬细胞中。将闪烁计数法获得的结果与光学显微镜检查获得的结果进行比较，可以认为肾脏中的放射性与肾小球毛细血管中的纤维蛋白沉积以及肝脏和脾脏中纤维蛋白（原）降解产物的积累相关。
