The origination and development of cervical cancer occurs in the tumor field, which includes cellular and non-cellular components of the connective tissue and vessels adjacent to the epithelium. During each of these phases of cancer growth alterations in these components may be observed within certain boundaries which widen with the tumor progression. A removal of the neoplasm within the limits of the unchanged, as compared with the normality, components of the stroma and vessels would guarantee against the recurrence and is a reliable criterion of the radicality of surgery being a minimum for preinvasive and microinvasive cancer. The data obtained support the fact of a sufficiently full coincidence of the rate of stromal and vascular changes with the true boundaries of the tumor field.
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