Kokoschka E M, Micksche M
Wien Klin Wochenschr. 1979 Mar 2;91(5):150-4.
Experimental data in animal models and clinical experience with a systemic immunotherapeutic approach in patients with tumours were the determining factors in the decision to test the local effect of this form of therapy on primary and secondary malignant lesion of the skin. The antitumour effect of local immunotherapy seems to be based on the induction of a cell-mediated immune challenge reaction in close contact with the malignant neoplasm. A trial of local immunotherapy was undertaken in 30 patients with melanoma with local recurrence of the primary tumour or multiple metastases involving the skin. The therapeutic indications and clinical response are discussed.
动物模型中的实验数据以及肿瘤患者全身免疫治疗方法的临床经验，是决定测试这种治疗形式对皮肤原发性和继发性恶性病变局部效果的决定性因素。局部免疫治疗的抗肿瘤作用似乎基于在与恶性肿瘤紧密接触部位诱导细胞介导的免疫攻击反应。对30例原发性肿瘤局部复发或有皮肤多发转移的黑色素瘤患者进行了局部免疫治疗试验。本文讨论了治疗指征及临床反应。
