Endler M, Hackel H
Wien Med Wochenschr. 1979 Feb 28;129(4):107-11.
40 patients with chronic osteomyelitis were treated per os with the bactericidal beta-lactam-antibiotic cephalexin during 3 to 60 weeks. In 16 patients, who were operated simultaneously, bacterial spreading was prevented by a combination of cephalexin and parenteral cephaloridin during operation and in the postoperative period. In these patients no recurrence occurred during the follow up time (2 to 5 years). In 34 patients general and local signs of inflammation diminished under cephalexin therapy and a complaint-free interval of at least 6 months followed. No serious side effects forcing a stop of therapy were observed. According to the gained experiences oral cephalexin in combination with perenteral cephaloridin is indicated for prevention of bacterial spreading during operations in chronic bone infections and in patients with acute febrile recurrence of chronic osteomyelitis refusing a surgical intervention.
40例慢性骨髓炎患者口服杀菌性β-内酰胺抗生素头孢氨苄治疗3至60周。其中16例同时接受手术治疗，术中及术后通过头孢氨苄与胃肠外头孢菌素联合使用防止细菌扩散。这些患者在随访期（2至5年）内未出现复发。34例患者在头孢氨苄治疗下炎症的全身及局部症状减轻，并随后有至少6个月的无主诉期。未观察到迫使停止治疗的严重副作用。根据所获经验，口服头孢氨苄联合胃肠外头孢菌素可用于预防慢性骨感染手术期间的细菌扩散，以及用于拒绝手术干预的慢性骨髓炎急性发热复发患者。
