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[Importance of chemico-biological interactions for the toxic and carcinogenic effect of aromatic amines. IV. Metabolic patterns of trans-4-demethylaminostilbene, cis-4-dimethylaminostilbene and 4-dimethylaminobibenzyl in liver, kidney and excretion products of the rat].

作者信息

Metzler M, Neumann H G

出版信息

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1971;76(1):16-39. doi: 10.1007/BF00304284.

DOI:10.1007/BF00304284
PMID:4255587
Abstract
摘要

相似文献

1
[Importance of chemico-biological interactions for the toxic and carcinogenic effect of aromatic amines. IV. Metabolic patterns of trans-4-demethylaminostilbene, cis-4-dimethylaminostilbene and 4-dimethylaminobibenzyl in liver, kidney and excretion products of the rat].[化学-生物相互作用对芳香胺毒性和致癌作用的重要性。IV. 反式-4-去甲基氨基芪、顺式-4-二甲基氨基芪和4-二甲基氨基联苄在大鼠肝脏、肾脏及排泄产物中的代谢模式]
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1971;76(1):16-39. doi: 10.1007/BF00304284.
2
[Importance of chemico-biological interactions for the toxic and carcinogenic effects of aromatic amines. II. Distribution of radioactivity after administration of tritium labelled carcinogen trans-4-dimethylaminostilbene and the noncarcinogenic cis-4-dimethylaminostilbene and dimethyl aminobibenzyl in the rat].
Z Krebsforsch. 1971 Feb 26;75(3):209-20.
3
The metabolism of repeatedly administered trans-4-dimethylaminostilbene and 4-dimethylaminobibenzyl.重复给药的反式-4-二甲基氨基芪和4-二甲基氨基联苄的代谢
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(1):60-70. doi: 10.1007/BF00284340.
4
The relevance of chemico-biological interactions for the toxic and carcinogenic effects of aromatic amines. V. The pharmacokinetics of related aromatic amines in blood.
Chem Biol Interact. 1972 May;4(6):409-19. doi: 10.1016/0009-2797(72)90061-0.
5
Significance of metabolic activation and binding to nucleic acids of aminostilbene derivatives in vivo.氨基芪衍生物在体内的代谢活化及与核酸结合的意义
Natl Cancer Inst Monogr. 1981 Dec(58):165-71.
6
The binding of metabolites formed from aminostilbene derivatives to nucleic acids in the liver of rats.氨基芪衍生物形成的代谢产物与大鼠肝脏中核酸的结合。
Chem Biol Interact. 1979 Mar;24(3):355-72. doi: 10.1016/0009-2797(79)90083-8.
7
Studies on trimetoquinol. I. Distribution, excretion and metabolism of trimetoquinol.
Biochem Pharmacol. 1970 Dec;19(12):2937-48. doi: 10.1016/0006-2952(70)90079-1.
8
The role of lipophilicity in the extrahepatic disposition of aminostilbene derivatives following administration to rat.亲脂性在大鼠给药后氨基芪衍生物肝外处置中的作用。
Xenobiotica. 1980 Sep;10(9):675-88. doi: 10.3109/00498258009108375.
9
Acute and chronic toxicity of aromatic amines studied in the isolated perfused rat liver.在离体灌注大鼠肝脏中研究芳香胺的急性和慢性毒性。
Toxicol Appl Pharmacol. 1996 Jul;139(1):186-94. doi: 10.1006/taap.1996.0157.
10
[The activation of carcinogenic aromatic amines in metabolism].[致癌性芳香胺在代谢中的活化作用]
Klin Wochenschr. 1970 Aug 15;48(16):959-66. doi: 10.1007/BF01484398.

引用本文的文献

1
Biomonitoring Human Albumin Adducts: The Past, the Present, and the Future.生物监测人白蛋白加合物：过去、现在与未来
Chem Res Toxicol. 2017 Jan 17;30(1):332-366. doi: 10.1021/acs.chemrestox.6b00366. Epub 2016 Dec 18.
2
Role of tissue exposure and DNA lesions for organ-specific effects of carcinogenic trans-4-acetylaminostilbene in rats.组织暴露和DNA损伤在致癌性反式-4-乙酰氨基芪对大鼠器官特异性作用中的作用。
Environ Health Perspect. 1983 Mar;49:51-8. doi: 10.1289/ehp.834951.
3
The metabolism of repeatedly administered trans-4-dimethylaminostilbene and 4-dimethylaminobibenzyl.

本文引用的文献

1
N-HYDROXYLATION IN AMINOSTIBENE CARCINOGENESIS.氨基芪致癌作用中的N-羟基化
Br J Cancer. 1965 Jun;19(2):433-43. doi: 10.1038/bjc.1965.52.
2
DIFFERENCES IN THE METABOLISM OF N-HYDROXY-N-2-FLUORENYLACETAMIDE IN MALE AND FEMALE RATS.雄性和雌性大鼠中N-羟基-N-2-芴基乙酰胺代谢的差异
Biochemistry. 1964 Jun;3:808-12. doi: 10.1021/bi00894a014.
3
CARCINOGENESIS AND INHIBITION OF THE WALKER 256 TUMOR IN THE RAT BY TRANS-4-ACETYLAMINOSTILBENE, ITS N-HYDROXY METABOLITE, AND RELATED COMPOUNDS.反式-4-乙酰氨基芪、其N-羟基代谢物及相关化合物对大鼠沃克256肿瘤的致癌作用与抑制作用
重复给药的反式-4-二甲基氨基芪和4-二甲基氨基联苄的代谢
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973;79(1):60-70. doi: 10.1007/BF00284340.
4
Methemoglobin formation and binding to blood constituents as indicators for the formation, availability and reactivity of activated metabolites derived from trans-4-aminostilbene and related aromatic amines.高铁血红蛋白的形成及其与血液成分的结合，作为反式-4-氨基芪及相关芳香胺衍生的活性代谢产物的形成、可用性和反应性的指标。
Arch Toxicol. 1978 Feb 21;40(1):17-35. doi: 10.1007/BF00353276.
Cancer Res. 1964 Jan;24:128-43.
4
A mechanism of orthol-hydroxylation of aromatic amines in vivo.体内芳香胺邻位羟基化的机制。
Biochim Biophys Acta. 1960 May 20;40:380-2. doi: 10.1016/0006-3002(60)91376-7.
5
Chromatographic separation of the urinary metabolites of the carcinogen N-2-fluorenylacetamide into free compounds, sulfuric acid, and glucuronic acid esters.将致癌物N-2-芴基乙酰胺的尿代谢物进行色谱分离，得到游离化合物、硫酸酯和葡萄糖醛酸酯。
Cancer Res. 1961 Aug;21:949-55.
6
Hydrolysis of ketosteroid hydrogen sulfates by solvolysis procedures.通过溶剂分解程序水解酮甾体硫酸氢盐。
J Biol Chem. 1958 Aug;233(2):331-5.
7
Chemistry, carcinogenicity, and metabolism of 2-fluorenamine and related compounds.2-芴胺及相关化合物的化学性质、致癌性和代谢
Adv Cancer Res. 1958;5:331-431. doi: 10.1016/s0065-230x(08)60415-7.
8
[Quantitative study of the carcinogenic effect of 4-amino-stilbenes].[4-氨基芪致癌作用的定量研究]
Z Krebsforsch. 1956;61(3):230-9.
9
Steroid conjugates; the separation of urinary 17-ketosteroid glucuronides and sulphates, and their composition in normal individuals.类固醇结合物；尿中17-酮类固醇葡萄糖醛酸苷和硫酸盐的分离及其在正常个体中的组成。
Acta Endocrinol (Copenh). 1956 Dec;23(4):357-70. doi: 10.1530/acta.0.0230357.
10
Biliary excretion of the O-glucuronide of N-hydroxy-2-acetylamino-fluorene by the rat and rabbit.
Cancer Res. 1967 Dec;27(12):2309-17.