[多发性硬化症的病因与发病机制]

[Etiology and pathogenesis of multiple sclerosis].

作者信息

Marchenkova R L, Komandenko N I, Skoromets A A

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1979;79(2):129-33.

Abstract

The features of the clinical picture and pathomorphology are analysed in 23 patients with disseminated sclerosis (in the acute, subacute and chronic phases). A clinico-anatomical observation of a subacute development of disseminated sclerosis is described in detail. Certain arguments distinguishing the subacute form of disseminated sclerosis of an infectious allergic nature are given (the traits of the clinical picture, morphological changes in the nervous system in the form of combined micronecrosis, pericellular oedema, different degrees of lymphocyte infiltration, extensive areas with accumulated oligodendroglia or fibrillar astrocytes with fresh and old foci of demyelinization).

摘要

对23例播散性硬化症患者（处于急性、亚急性和慢性期）的临床表现和病理形态学特征进行了分析。详细描述了播散性硬化症亚急性发展过程的临床解剖学观察结果。给出了一些将具有感染性过敏性质的播散性硬化症亚急性形式区分开来的论据（临床表现特征、神经系统的形态学变化，表现为混合性微坏死、细胞周围水肿、不同程度的淋巴细胞浸润、有大量少突胶质细胞或纤维性星形胶质细胞聚集的区域以及新老脱髓鞘病灶）。