Barranger J A, Geiger P J, Huzino A, Bessman S P
Science. 1972 Feb 25;175(4024):903-5. doi: 10.1126/science.175.4024.903.
Three isozymes of phenylalanine hydroxylase exist in adult rat liver. They are chromatographically unique. Partial chracterization suggests that they are similar in chemical properties and differ only in charge. Estimation of the Stokes radii indicates that the isozymes have similar molecular weights of about 200,000. Two isozymes exist in human fetal liver. Alterations of the relative amounts of these isozymes may control the phenotype of the disease phenylketonuria.
成年大鼠肝脏中存在三种苯丙氨酸羟化酶同工酶。它们在色谱上具有独特性。部分特性表明它们在化学性质上相似，仅电荷不同。斯托克斯半径的估计表明这些同工酶的分子量相似，约为200,000。人类胎儿肝脏中存在两种同工酶。这些同工酶相对含量的改变可能控制苯丙酮尿症的疾病表型。
