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[小剂量酒精对颅脑损伤晚期后遗症患者情绪应激的影响]

[Effect of small doses of alcohol on emotional stress in patients with late sequelae of cranio-cerebral injuries].

作者信息

Zakharova N N

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1979;79(2):195-201.

PMID:425767
Abstract

An experimental study of individuals with late sequelae of closed cerebrocranial trauma, demonstrated that diverse signs of CNS activity to a different extent may be under the influence of small doses of alcohol. For instance, the sensorial process does not change significantly, which may indicate a relative independence of specific sensorial pathways (including the cortical area) from small doses of alcohol. Changes in cortical electro-activity and the threshold of the orientation reflex, the mechanisms of which are connected with the function of the brain stem reticular formation, points to an inhibitory action of alcohol on it. Against the background of alcoholic influence the socially significant emotionally negative stimula intensify emotional stress, the action of which is related to the activity of the limbic system structures and a weakening of the function of associative cortical fields. The results of this study permit to assume that different functional-structural mechanisms may lie at the basis of an emotional background (mood) and emotional stress.

摘要

一项针对闭合性颅脑创伤后遗症患者的实验研究表明,小剂量酒精可能在不同程度上影响中枢神经系统活动的多种体征。例如,感觉过程没有明显变化,这可能表明特定感觉通路(包括皮质区域)相对独立于小剂量酒精。皮质电活动和定向反射阈值的变化,其机制与脑干网状结构的功能相关,表明酒精对其具有抑制作用。在酒精影响的背景下,具有社会意义的情绪负面刺激会加剧情绪应激,其作用与边缘系统结构的活动以及联合皮质区域功能的减弱有关。这项研究的结果表明,不同的功能 - 结构机制可能是情绪背景(情绪)和情绪应激的基础。

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