Kaukinen S, Pyykkö K
Acta Anaesthesiol Scand. 1979 Feb;23(1):107-11. doi: 10.1111/j.1399-6576.1979.tb01429.x.
The antihypertensive agent, clonidine, has a marked sedative effect. We studied whether clonidine also deepens halothane anaesthesia. Eight rabbits were anaesthetized with and without clonidine premedication in a cross-over study. Clonidine premedication (50 microgram/kg subcutaneously) was administered three times daily for 3 days. Tolerance to pain during halothane anaesthesia was tested by compressing the ear with a vessel clamp. Halothane concentrations were determined by gas chromatography. The rabbits premedicated with clonidine tolerated painful stimuli without reactions at lower halothane concentrations in arterial blood and inspired air than unpremedicated rabbits. MAC calculated from blood concentrations was 1.29% for unpremedicated and 1.09% for clonidine-premedicated rabbits. The results suggest that clonidine diminishes the anaesthetic requirement in halothane anaesthesia.
抗高血压药可乐定具有显著的镇静作用。我们研究了可乐定是否也会加深氟烷麻醉。在一项交叉研究中，对8只兔子进行了有无可乐定术前用药的麻醉。可乐定术前用药（皮下注射50微克/千克），每天给药3次，共3天。通过用血管夹压迫耳朵来测试氟烷麻醉期间对疼痛的耐受性。通过气相色谱法测定氟烷浓度。与未进行术前用药的兔子相比，术前用可乐定处理的兔子在动脉血和吸入气中氟烷浓度较低时就能耐受疼痛刺激而无反应。根据血药浓度计算出的未进行术前用药兔子的最低肺泡有效浓度（MAC）为1.29%，术前用可乐定处理的兔子为1.09%。结果表明，可乐定可降低氟烷麻醉时的麻醉需求。
