烟草烟雾诱导大鼠气道黏液糖蛋白分泌过多。
Hypersecretion of mucus glycoproteins in rat airways induced by tobacco smoke.
作者信息
Coles S J, Levine L R, Reid L
出版信息
Am J Pathol. 1979 Mar;94(3):459-72.
Abstract
An animal model of chronic bronchitis has been produced in vivo by exposing rats for 6 weeks to tobacco smoke: the laryngeal and tracheal glands have been studied in vitro by organ culture to analyze glycoprotein precursor incorporation and glycoprotein secretion by individual cells, a feature not previously studied. In the hypertrophied glands produced by tobacco smoke exposure, the cellular rate of glycoprotein secretion was increased. The in vivo administration of phenylmethyloxadiazole (PMO) to rats exposed to tobacco smoke blocked this effect. In vitro analysis of glands from unexposed rats that received PMO showed that it modified cell function directly by reducing the rates both of glycoprotein discharge and or precursor incorporation into intracellular glycoproteins.
摘要
通过让大鼠暴露于香烟烟雾中6周，已在体内建立了慢性支气管炎动物模型：通过器官培养在体外研究了喉和气管腺，以分析单个细胞中糖蛋白前体的掺入和糖蛋白分泌情况，这一特征以前未曾研究过。在因暴露于香烟烟雾而产生的肥大腺体中，糖蛋白的细胞分泌率增加。对暴露于香烟烟雾的大鼠进行体内苯甲基恶二唑（PMO）给药可阻断这种作用。对接受PMO的未暴露大鼠的腺体进行体外分析表明，它通过降低糖蛋白释放率和前体掺入细胞内糖蛋白的速率直接改变细胞功能。
相似文献
1
Hypersecretion of mucus glycoproteins in rat airways induced by tobacco smoke.烟草烟雾诱导大鼠气道黏液糖蛋白分泌过多。
Am J Pathol. 1979 Mar;94(3):459-72.
2
3
Mucin-producing elements and inflammatory cells.产生黏蛋白的成分和炎症细胞。
Novartis Found Symp. 2002;248:51-68; discussion 68-75, 277-82.
4
Secretory cells.分泌细胞
Fed Proc. 1977 Dec;36(13):2703-7.
5
Effect of epithelium on mucus secretion from feline tracheal submucosal glands.上皮对猫气管黏膜下腺黏液分泌的影响。
J Appl Physiol (1985). 1989 Feb;66(2):764-70. doi: 10.1152/jappl.1989.66.2.764.
6
Non-allergic models of mucous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways.大鼠鼻和肺气道黏液细胞化生及黏液分泌亢进的非过敏性模型
Novartis Found Symp. 2002;248:181-97; discussion 197-200, 277-82.
7
8
9
The effect of tobacco smoke, with or without phenylmethyloxadiazole (PMO), on rat bronchial epithelium: a light and electron microscopic study.有或无苯甲基恶二唑（PMO）的烟草烟雾对大鼠支气管上皮的影响：光镜和电镜研究
J Pathol. 1981 Apr;133(4):341-59. doi: 10.1002/path.1711330406.
引用本文的文献
1
Airway Epithelium Dysfunction in Cystic Fibrosis and COPD.气道上皮功能障碍在囊性纤维化和 COPD 中的作用。
Mediators Inflamm. 2018 Apr 8;2018:1309746. doi: 10.1155/2018/1309746. eCollection 2018.
2
Airway hydration and COPD.气道水化与慢性阻塞性肺疾病
Cell Mol Life Sci. 2015 Oct;72(19):3637-52. doi: 10.1007/s00018-015-1946-7. Epub 2015 Jun 12.
3
Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface.香烟烟雾会改变气液界面处原代人支气管上皮细胞的分化。
Sci Rep. 2015 Feb 2;5:8163. doi: 10.1038/srep08163.
4
Asian sand dust enhances allergen-induced th2 allergic inflammatory changes and mucin production in BALB/c mouse lungs.亚洲沙尘增强过敏原诱导的 BALB/c 鼠肺部 th2 过敏性炎症变化和粘蛋白产生。
Allergy Asthma Immunol Res. 2012 Jul;4(4):206-13. doi: 10.4168/aair.2012.4.4.206. Epub 2012 Mar 9.
5
Effect of active smoking on the human bronchial epithelium transcriptome.主动吸烟对人支气管上皮转录组的影响。
BMC Genomics. 2007 Aug 29;8:297. doi: 10.1186/1471-2164-8-297.
6
Signaling networks controlling mucin production in response to Gram-positive and Gram-negative bacteria.响应革兰氏阳性菌和革兰氏阴性菌控制粘蛋白产生的信号网络。
Glycoconj J. 2001 Sep;18(9):715-22. doi: 10.1023/a:1020875423678.
7
Mucin secretion in the rat tracheal epithelial cells by epidermal growth factor and Pseudomonas aeruginosa extracts.表皮生长因子和铜绿假单胞菌提取物对大鼠气管上皮细胞黏蛋白分泌的影响
Korean J Intern Med. 2001 Sep;16(3):167-72. doi: 10.3904/kjim.2001.16.3.167.
8
Role of epidermal growth factor receptor activation in regulating mucin synthesis.表皮生长因子受体激活在调节黏蛋白合成中的作用。
Respir Res. 2001;2(2):85-9. doi: 10.1186/rr43. Epub 2001 Feb 21.
9
Effect of retinoic acid on mucin gene expression in rat airways in vitro.维甲酸对大鼠气道黏蛋白基因体外表达的影响。
Biochem J. 1994 Jan 15;297 ( Pt 2)(Pt 2):309-13. doi: 10.1042/bj2970309.
10
The role of airway mucus in pulmonary toxicology.气道黏液在肺部毒理学中的作用。
Environ Health Perspect. 1994 Jun;102 Suppl 2(Suppl 2):89-103. doi: 10.1289/ehp.9410289.
本文引用的文献
1
The effect of cigarette smoke on the respiratory system of the rabbit. A final report.香烟烟雾对家兔呼吸系统的影响。最终报告。
Cancer. 1963 May;16:612-5. doi: 10.1002/1097-0142(196305)16:5<612::aid-cncr2820160511>3.0.co;2-8.
2
A simple photometric device for the quantitation of silver grains in autoradiographs of tissue sections.一种用于定量组织切片放射自显影片中银颗粒的简易光度测定装置。
Exp Cell Res. 1961 Aug;24:228-39. doi: 10.1016/0014-4827(61)90425-6.
3
The culture of mature organs in a synthetic medium.在合成培养基中对成熟器官进行培养。
Exp Cell Res. 1959 Jan;16(1):118-47. doi: 10.1016/0014-4827(59)90201-0.
4
A new change-over optical system and a direct recording microscope for quantitative autoradiography.一种用于定量放射自显影的新型转换光学系统和直接记录显微镜。
Exp Cell Res. 1957;13(Suppl 4):222-30.
5
Histologic changes in bronchial tubes of cigarette-smoking dogs.吸烟犬支气管的组织学变化。
Cancer. 1967 Dec;20(12):2055-66. doi: 10.1002/1097-0142(196712)20:12<2055::aid-cncr2820201202>3.0.co;2-m.
6
7
Goblet cell increase in rat bronchial epithelium after exposure to cigarette and cigar tobacco smoke.暴露于香烟和雪茄烟雾后大鼠支气管上皮杯状细胞增多。
Br Med J. 1969 Jan 4;1(5635):33-5. doi: 10.1136/bmj.1.5635.33.
8
Mitotic rates, goblet cell increase and histochemical changes in mucus in rat bronchial epithelium during exposure to sulphur dioxide.
J Pathol Bacteriol. 1968 Jul;96(1):97-111. doi: 10.1002/path.1700960111.
9
The biosynthesis of intestinal mucins. The effect of salicylate on glycoprotein biosynthesis by sheep colonic and human gastric mucosal tissues in vitro.肠道黏蛋白的生物合成。水杨酸盐对绵羊结肠和人胃黏膜组织体外糖蛋白生物合成的影响。
Biochem J. 1968 Feb;106(3):645-58. doi: 10.1042/bj1060645.
10
Mode of stabilizing action of non-steroid anti-inflammatory drugs on erythrocyte membrane.非甾体抗炎药对红细胞膜的稳定作用模式。
Biochem Pharmacol. 1970 Jan;19(1):227-34. doi: 10.1016/0006-2952(70)90343-6.
Zotero 插件