氯丙嗪对用单胺氧化酶抑制剂处理的大鼠中由L-色氨酸或5-甲氧基-N，N-二甲基色胺产生的多动综合征的抑制作用。
Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by L-tryptophan or 5-methoxy-N,N-dimethyltryptamine in rats treated with a monoamine oxidase inhibitor.
作者信息
Grahame-Smith D G
出版信息
Br J Pharmacol. 1971 Dec;43(4):856-64. doi: 10.1111/j.1476-5381.1971.tb07222.x.
Abstract
- The hyperactivity and hyperpyrexia produced by L-tryptophan in rats treated with a monoamine oxidase inhibitor was inhibited by chlorpromazine.2. Chlorpromazine did not inhibit the increased rate of synthesis of brain 5-hydroxytryptamine (5-HT) produced by tryptophan loading.3. Hyperactivity and hyperpyrexia were also produced by 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) in rats. Pretreatment with a monoamine oxidase inhibitor potentiated the hyperactivity response. Pretreatment of rats with p-chlorophenylalanine did not inhibit hyperactivity produced by 5-MeODMT.4. Chlorpromazine inhibits hyperactivity caused by tryptophan or 5-MeODMT after monoamine oxidase inhibition either by competition with 5-HT or 5-MeODMT, respectively, at receptor sites or by physiological antagonism.
摘要
氯丙嗪可抑制用单胺氧化酶抑制剂处理的大鼠中L-色氨酸产生的多动和高热。
氯丙嗪不抑制色氨酸负荷所引起的脑5-羟色胺（5-HT）合成速率的增加。
5-甲氧基-N,N-二甲基色胺（5-MeODMT）在大鼠中也会产生多动和高热。用单胺氧化酶抑制剂预处理可增强多动反应。用对氯苯丙氨酸预处理大鼠并不能抑制5-MeODMT所引起的多动。
氯丙嗪在单胺氧化酶被抑制后，通过分别在受体部位与5-HT或5-MeODMT竞争，或通过生理拮抗作用，抑制色氨酸或5-MeODMT所引起的多动。
相似文献
1
Inhibitory effect of chlorpromazine on the syndrome of hyperactivity produced by L-tryptophan or 5-methoxy-N,N-dimethyltryptamine in rats treated with a monoamine oxidase inhibitor.氯丙嗪对用单胺氧化酶抑制剂处理的大鼠中由L-色氨酸或5-甲氧基-N，N-二甲基色胺产生的多动综合征的抑制作用。
Br J Pharmacol. 1971 Dec;43(4):856-64. doi: 10.1111/j.1476-5381.1971.tb07222.x.
2
The role of brain 5-hydroxytryptamine in the hyperactivity produced in rats by lithium and monoamine oxidase inhibition.脑5-羟色胺在锂和单胺氧化酶抑制所致大鼠多动中的作用。
Br J Pharmacol. 1974 Sep;52(1):19-26. doi: 10.1111/j.1476-5381.1974.tb09682.x.
3
The prevention by inhibitors of brain proptein synthesis of the hyperactivity and hyperpyrexia produced in rats by monoamine oxidase inhibition and the administration of L-tryptophan or 5-methoxy-N,N-dimethyltryptamine.通过抑制脑蛋白合成来预防单胺氧化酶抑制以及给予L-色氨酸或5-甲氧基-N，N-二甲基色胺后在大鼠中产生的多动和高热。
J Neurochem. 1972 Oct;19(10):2409-22. doi: 10.1111/j.1471-4159.1972.tb01295.x.
4
Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan.关于用单胺氧化酶抑制剂和L-色氨酸处理的大鼠中脑色氨酸、脑5-羟色胺合成与多动之间关系的体内研究。
J Neurochem. 1971 Jun;18(6):1053-66. doi: 10.1111/j.1471-4159.1971.tb12034.x.
5
The effect of inhibitors of protein synthesis to inhibit brain protein synthesis and prevent the hyperactivity and hyperpyrexia in rats produced by inhibition of monoamine oxidase and the administration of L-tryptophan or 5-methoxy-NN-dimethyltryptamine.蛋白质合成抑制剂对抑制大鼠脑蛋白质合成以及预防因抑制单胺氧化酶并给予L-色氨酸或5-甲氧基-N，N-二甲基色胺所产生的多动和高热的作用。
Biochem J. 1972 Apr;127(2):7P. doi: 10.1042/bj1270007pc.
6
Repeated chlorpromazine administration increases a behavioural response of rats to 5-hydroxytryptamine receptor stimulation.重复给予氯丙嗪会增强大鼠对5-羟色胺受体刺激的行为反应。
Br J Pharmacol. 1977 Feb;59(2):367-71. doi: 10.1111/j.1476-5381.1977.tb07501.x.
7
The effects of putative 5-hydroxytryptamine antagonists on the behaviour produced by administration of tranylcypromine and L-tryptophan or tranylcypromine and L-DOPA to rats.假定的5-羟色胺拮抗剂对给大鼠注射反苯环丙胺与L-色氨酸或反苯环丙胺与L-多巴所产生行为的影响。
Br J Pharmacol. 1978 Oct;64(2):201-9. doi: 10.1111/j.1476-5381.1978.tb17290.x.
8
Effects of monoamine oxidase inhibition by clorgyline, deprenil or tranylcypromine on 5-hydroxytryptamine concentrations in rat brain and hyperactivity following subsequent tryptophan administration.氯吉兰、丙炔苯丙胺或反苯环丙胺抑制单胺氧化酶对大鼠脑内5-羟色胺浓度及随后给予色氨酸后的多动的影响。
Br J Pharmacol. 1975 Nov;55(3):415-22. doi: 10.1111/j.1476-5381.1975.tb06946.x.
9
A behavioural and biochemical study in rats of 5-hydroxytryptamine receptor agonists and antagonists, with observations on structure-activity requirements for the agonists.一项关于5-羟色胺受体激动剂和拮抗剂在大鼠身上的行为与生化研究，并对激动剂的构效关系要求进行了观察。
Br J Pharmacol. 1981 Jul;73(3):703-19. doi: 10.1111/j.1476-5381.1981.tb16806.x.
10
Elevation of brain GABA concentrations with amino-oxyacetic acid; effect on the hyperactivity syndrome produced by increased 5-hydroxytryptamine synthesis in rats.用氨基氧乙酸提高脑内γ-氨基丁酸浓度；对大鼠因5-羟色胺合成增加所致多动综合征的影响
J Neural Transm. 1976;39(1-2):103-12. doi: 10.1007/BF01248769.
引用本文的文献
1
5-MeO-DMT: An atypical psychedelic with unique pharmacology, phenomenology & risk?5-甲氧基-N,N-二甲基色胺：一种具有独特药理学、现象学及风险的非典型致幻剂？
Psychopharmacology (Berl). 2023 Dec 11. doi: 10.1007/s00213-023-06517-1.
2
A narrative synthesis of research with 5-MeO-DMT.5-MeO-DMT 研究的叙事综合
J Psychopharmacol. 2022 Mar;36(3):273-294. doi: 10.1177/02698811211050543. Epub 2021 Oct 19.
3
Behavioral and pharmacokinetic interactions between monoamine oxidase inhibitors and the hallucinogen 5-methoxy-N,N-dimethyltryptamine.单胺氧化酶抑制剂与致幻剂5-甲氧基-N,N-二甲基色胺之间的行为和药代动力学相互作用。
Pharmacol Biochem Behav. 2016 Apr;143:1-10. doi: 10.1016/j.pbb.2016.01.005. Epub 2016 Jan 15.
4
Characterization of serotonin-toxicity syndrome (toxidrome) elicited by 5-hydroxy-l-tryptophan in clorgyline-pretreated rats.对氯吉兰预处理大鼠中5-羟色氨酸引发的血清素中毒综合征（中毒症候群）的特征描述。
Eur J Pharmacol. 2008 Jul 7;588(2-3):198-206. doi: 10.1016/j.ejphar.2008.04.004. Epub 2008 Apr 8.
5
Neuropharmacology of 5-hydroxytryptamine.5-羟色胺的神经药理学
Br J Pharmacol. 2006 Jan;147 Suppl 1(Suppl 1):S145-52. doi: 10.1038/sj.bjp.0706427.
6
The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats.给大鼠施用3,4-亚甲基二氧甲基苯丙胺（MDMA，“摇头丸”）后急性体温过高反应的药理学。
Br J Pharmacol. 2002 Jan;135(1):170-80. doi: 10.1038/sj.bjp.0704442.
7
Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing.8-羟基二苯丙氨酸（8-OHDPAT）以及5-羟色胺1A（5-HT1A）拮抗剂WAY100135和WAY100635对豚鼠行为及中缝背核5-羟色胺能神经元放电的影响。
Br J Pharmacol. 1996 Feb;117(4):750-6. doi: 10.1111/j.1476-5381.1996.tb15254.x.
8
An ethopharmacological analysis of the behavioral effects of 8-OH-DPAT.8-羟基二苯丙氨酸行为效应的行为药理学分析。
Psychopharmacology (Berl). 1993;112(1):55-63. doi: 10.1007/BF02247363.
9
Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy").3,4－亚甲基二氧甲基苯丙胺（摇头丸或“迷幻药”）的药理学与临床药理学综述
Psychopharmacology (Berl). 1995 Jun;119(3):247-60. doi: 10.1007/BF02246288.
10
The effects of 5-HT uptake- and MAO-inhibitors on L-5-HTP-induced excitation in rats.5-羟色胺摄取抑制剂和单胺氧化酶抑制剂对大鼠L-5-羟色胺酸诱导兴奋的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1980 Mar;311(2):185-92. doi: 10.1007/BF00510258.
本文引用的文献
1
Aromatic L-amino acid decarboxylase.芳香族L-氨基酸脱羧酶
J Biol Chem. 1962 Jan;237:89-93.
2
Behavioral effects and brain amine content in rats.大鼠的行为效应与脑胺含量
Arch Int Pharmacodyn Ther. 1961 Nov 1;134:89-99.
3
[The effect of chlorpromazine on catecholamine and 5-hydroxytryptamine metabolism in the rat brain].[氯丙嗪对大鼠脑内儿茶酚胺和5-羟色胺代谢的影响]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1960;239:507-19.
4
The biosynthesis of 5-hydroxytryptamine in brain.大脑中5-羟色胺的生物合成。
Biochem J. 1967 Oct;105(1):351-60. doi: 10.1042/bj1050351.
5
The determination of tryptophan in plasma, liver, and urine.血浆、肝脏及尿液中色氨酸的测定。
J Lab Clin Med. 1967 Jan;69(1):160-9.
6
Some studies of the effects of chlorpromazine, reserpine and dihydroxyphenylalanine on the concentrations of homovanillic acid, 3,4-dihydroxyphenylacetic acid and 5-hydroxyindol-3-ylacetic acid in ventricular cerebrospinal fluid of the dog using the technique of serial sampling of the cerebrospinal fluid.一些关于氯丙嗪、利血平和二羟基苯丙氨酸对犬脑室脑脊液中高香草酸、3,4-二羟基苯乙酸和5-羟基吲哚-3-乙酸浓度影响的研究，采用了脑脊液连续采样技术。
Br J Pharmacol Chemother. 1968 Jul;33(3):457-71. doi: 10.1111/j.1476-5381.1968.tb00494.x.
7
Fate and metabolism of some hallucinogenic indolealkylamines.某些致幻吲哚烷基胺的命运与代谢
Adv Pharmacol (1962). 1968;6(Pt B):213-29. doi: 10.1016/s1054-3589(08)60320-8.
8
A rapid and sensitive procedure for the combined assay of noradrenaline, dopamine AND SEROTONIN IN A SINGLE BRAIN SAMPLE.一种在单一样本大脑中联合检测去甲肾上腺素、多巴胺和5-羟色胺的快速灵敏方法。
Anal Biochem. 1968 May;23(2):196-206. doi: 10.1016/0003-2697(68)90351-5.
9
Phenelzine poisoning responding to phenothiazine.对吩噻嗪有反应的苯乙肼中毒
Med J Aust. 1969 Dec 13;2(24):1214-5.
10
Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan.关于用单胺氧化酶抑制剂和L-色氨酸处理的大鼠中脑色氨酸、脑5-羟色胺合成与多动之间关系的体内研究。
J Neurochem. 1971 Jun;18(6):1053-66. doi: 10.1111/j.1471-4159.1971.tb12034.x.
Zotero 插件