Omeñaca F, Navarro C, Barrio C, Pérez Rodríguez J, García Frías E, Quero J, Moreno F
An Esp Pediatr. 1979 Feb;12(2):123-30.
Three patients with Meconium Aspiration Syndrome (S.A.M.) and severe hypoxemia are reported. From the first hours of life they needed mechanical ventilation, showing no improvement in PaO2 in spite of usual respiratory support measures. In one case, pulmonary hypertension and ductal right to left shunt through ductus arteriosus and foramen ovale was objetivated by cardiac catheterization. Following intravenous prefusion of a pulmonary vasodilator (Tolazoline) patients showed a clinical amelioration and a definite increase in PaO2. Results and evolution with the use of this drug are commented.
报告了3例患有胎粪吸入综合征（S.A.M.）和严重低氧血症的患者。从出生后的最初几个小时起，他们就需要机械通气，尽管采取了常规的呼吸支持措施，但动脉血氧分压（PaO2）并无改善。在1例病例中，通过心导管检查确定存在肺动脉高压以及经动脉导管和卵圆孔的右向左分流。在静脉预注一种肺血管扩张剂（妥拉唑啉）后，患者的临床症状有所改善，PaO2明显升高。对使用该药物的结果及病情发展进行了评论。
