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Evaluation of the enterohepatic circulation after 3 H-digoxin administration in the rat.

作者信息

Abshagen U, von Bergmann K, Rietbrock N

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1972;275(1):1-10. doi: 10.1007/BF00505063.

DOI:10.1007/BF00505063
PMID:4264167
Abstract
摘要

相似文献

1
Evaluation of the enterohepatic circulation after 3 H-digoxin administration in the rat.大鼠给予3H-地高辛后肠肝循环的评估。
Naunyn Schmiedebergs Arch Pharmacol. 1972;275(1):1-10. doi: 10.1007/BF00505063.
2
Pharmacokinetics and metabolism of alpha-acetyldigoxin in man.α-乙酰地高辛在人体中的药代动力学与代谢
Arch Int Pharmacodyn Ther. 1974 Mar;208(1):102-16.
3
[Determination of the intestinal absorption of cardiac glycosides by measurement of 3H-labelled glycosides in the portal venous blood and in the intestinal lymph of cats].[通过测量猫门静脉血和肠淋巴液中3H标记的强心苷来测定强心苷的肠道吸收]
Naunyn Schmiedebergs Arch Pharmakol. 1969;264(4):406-19.
4
A method for investigation of enterohepatic circulation.一种肠肝循环的研究方法。
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(2):208-10. doi: 10.1007/BF00501857.
5
-methyl-digoxin. IV. Blood levels, tissue distribution and metabolism in the guinea-pig.甲基地高辛。四、豚鼠体内血药浓度、组织分布及代谢
Naunyn Schmiedebergs Arch Pharmacol. 1972;272(1):46-64. doi: 10.1007/BF00498793.
6
[Metabolism and kinetics of -acetyldigoxin].[乙酰地高辛的代谢与动力学]
Klin Wochenschr. 1972 Feb 15;50(4):191-5. doi: 10.1007/BF01487142.
7
Pharmacokinetics of digoxin and its 4'''-acetyl- and methylderivates in the rat.地高辛及其4'''-乙酰基和甲基衍生物在大鼠体内的药代动力学。
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(2):171-81. doi: 10.1007/BF00501851.
8
Interruption of the enterohepatic circulation of digitoxin by cholestyramine. I. Protection against lethal digitoxin intoxication.考来烯胺对洋地黄毒苷肝肠循环的阻断作用。I. 对致死性洋地黄毒苷中毒的保护作用。
J Clin Invest. 1971 Dec;50(12):2626-37. doi: 10.1172/JCI106763.
9
Tritiated digoxin. XIV. Enterohepatic circulation, absorption, and excretion studies in human volunteers.
Circulation. 1970 Nov;42(5):867-73. doi: 10.1161/01.cir.42.5.867.
10
Plasma concentration, uptake by liver, and biliary excretion of tritiated cardiac glycosides in the isolated perfused guinea-pig liver.离体灌注豚鼠肝脏中氚标记强心苷的血浆浓度、肝脏摄取及胆汁排泄
Br J Pharmacol. 1971 Apr;41(4):648-60. doi: 10.1111/j.1476-5381.1971.tb07073.x.

引用本文的文献

1
Modification of the P-glycoprotein dependent pharmacokinetics of digoxin in rats by human recombinant interferon-alpha.人重组干扰素-α对大鼠体内地高辛依赖P-糖蛋白的药代动力学的影响
Pharm Res. 2005 Nov;22(11):1829-36. doi: 10.1007/s11095-005-7415-5. Epub 2005 Aug 16.
2
Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein.地高辛通过肠黏膜大量排泄，以及多药耐药蛋白1a（mdr 1a）P-糖蛋白防止地高辛在大脑中长期蓄积。
Br J Pharmacol. 1996 Nov;119(5):1038-44. doi: 10.1111/j.1476-5381.1996.tb15775.x.
3
Hepatic clearance of gitoxin: pharmacokinetic study on rabbit isolated liver. Influence of protein binding and comparison with digoxin.

本文引用的文献

1
Species difference in duration of action of cardiac glycosides.强心苷作用持续时间的种属差异。
Fed Proc. 1967 Jul-Aug;26(4):1125-30.
2
Biotransformation of digitoxin in the dog.洋地黄毒苷在犬体内的生物转化
J Pharmacol Exp Ther. 1966 Dec;154(3):575-80.
3
Excretion of radioactive digitoxin by the dog.狗对放射性洋地黄毒苷的排泄。
地高辛毒苷的肝清除率：兔离体肝脏的药代动力学研究。蛋白结合的影响及与地高辛的比较。
Eur J Drug Metab Pharmacokinet. 1983;8(1):1-8. doi: 10.1007/BF03189574.
4
Pharmacokinetics and metabolism of digoxigenin-mono-digitoxoside in man.洋地黄毒苷元-单洋地黄毒糖苷在人体内的药代动力学与代谢
Eur J Clin Pharmacol. 1974;7(2):87-94. doi: 10.1007/BF00561320.
5
Formation and disposition of bis- and monoglycosides after administration of 3H-4'''-methyldigoxin to man.人体给予3H-4'''-甲基地高辛后双糖苷和单糖苷的形成与分布。
Eur J Clin Pharmacol. 1974;7(3):177-81. doi: 10.1007/BF00560378.
6
Metabolism of digoxigenin, digoxigeninmonodigitoxoside and digoxigeninbisdigitoxoside in rats.
Naunyn Schmiedebergs Arch Pharmacol. 1973;276(2):157-66. doi: 10.1007/BF00501188.
7
A method for investigation of enterohepatic circulation.一种肠肝循环的研究方法。
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(2):208-10. doi: 10.1007/BF00501857.
8
Pharmacokinetics of digoxin and its 4'''-acetyl- and methylderivates in the rat.地高辛及其4'''-乙酰基和甲基衍生物在大鼠体内的药代动力学。
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(2):171-81. doi: 10.1007/BF00501851.
J Pharmacol Exp Ther. 1965 Aug;149(2):257-62.
4
[Distribution and biotransformation of various cardiac glycosides].[各种强心苷的分布与生物转化]
Dtsch Med Wochenschr. 1971 Jun 4;96(23):1018-21. doi: 10.1055/s-0028-1108376.
5
A method for investigation of enterohepatic circulation.一种肠肝循环的研究方法。
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(2):208-10. doi: 10.1007/BF00501857.
6
Pharmacokinetics of digoxin and its 4'''-acetyl- and methylderivates in the rat.地高辛及其4'''-乙酰基和甲基衍生物在大鼠体内的药代动力学。
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(2):171-81. doi: 10.1007/BF00501851.
7
Quantitative analysis of digoxin, 4'''-acetyldigoxin and 4'''-methyldigoxin and their metabolites in bile and urine of rats.大鼠胆汁和尿液中地高辛、4'''-乙酰地高辛、4'''-甲基地高辛及其代谢产物的定量分析
Naunyn Schmiedebergs Arch Pharmacol. 1972;273(1):154-67. doi: 10.1007/BF00508087.