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核型不平衡导致的猪胚胎死亡。

Embryonic death in pigs caused by unbalanced karyotype.

作者信息

Akesson A, Henricson B

出版信息

Acta Vet Scand. 1972;13(2):151-60. doi: 10.1186/BF03548568.

DOI:10.1186/BF03548568
PMID:4265712
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8561448/
Abstract

A landrace boar being heterozygous for a translocation has been used in 43 matings to 30 sows. Compared to a normal boar which also served part of the same sow group the defect boar had a by 30 % reduced fertility. Five different types of unbalanced karyotypes were detected in fetuses sired by the translocation heterozygote. Since no unbalanced karyotype was to be found postnatally in 111 offspring, all defect karyotypes seem to be lethal at the embryonic stage. Forty-one % of the postnatally investigated cases had the same translocation as the father.

摘要

一头携带易位杂合子的地方品种公猪与30头母猪进行了43次交配。与同样为同一组母猪配种的正常公猪相比,这头有缺陷的公猪生育力降低了30%。在这头易位杂合子公猪所产的胎儿中检测到了五种不同类型的不平衡核型。由于在111头后代中出生后未发现不平衡核型,所有有缺陷的核型在胚胎阶段似乎都是致死的。出生后调查的病例中有41%与父亲有相同的易位。

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Embryonic death in pigs caused by unbalanced karyotype.核型不平衡导致的猪胚胎死亡。
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引用本文的文献

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A Cytogenetic Study of Repeat-breeder Heifers and Their Embryos.重复配种小母牛及其胚胎的细胞遗传学研究。
Can Vet J. 1983 Apr;24(4):112-5.
2
Chromosome segregation into the spermatozoa of two men heterozygous for different reciprocal translocations.染色体分离到两名男性精子中,这两名男性对于不同的相互易位是杂合子。
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Laboratory diagnosis of swine diseases.猪病的实验室诊断
Vet Clin North Am Large Anim Pract. 1982 Nov;4(2):201-23. doi: 10.1016/s0196-9846(17)30103-9.

本文引用的文献

1
DISTRIBUTIVE PAIRING AND ANEUPLOIDY IN MAN.人类的分配配对与非整倍体
Science. 1964 Jul 3;145(3627):66-7. doi: 10.1126/science.145.3627.66.
2
A simple method for short term cultures from small biopsies.一种从小活检样本进行短期培养的简单方法。
Exp Cell Res. 1963 Mar;30:229-32. doi: 10.1016/0014-4827(63)90230-1.
3
Chromosome preparations of leukocytes cultured from human peripheral blood.从人外周血培养的白细胞的染色体标本制备。
Exp Cell Res. 1960 Sep;20:613-6. doi: 10.1016/0014-4827(60)90138-5.
4
Chromosome abnormalities in early embryos of the pig.猪早期胚胎中的染色体异常
J Reprod Fertil. 1967 Jun;13(3):579-81. doi: 10.1530/jrf.0.0130579.