Krediet R T, Dunning A J
Br Heart J. 1979 Jan;41(1):106-10. doi: 10.1136/hrt.41.1.106.
Baroreceptor function was measured in 18 patients with essential hypertension by plotting the change in pulse interval against a phenylephrine-induced transient rise in systolic blood pressure. The influence of propranolol (160 mg daily for at least 4 weeks) on this function and on heart rate after maximal exercise was studied and correlated with the plasma propranolol level. In 13 out of the 18 patients only baroreflex resetting occurred with no change in sensitivity during propranolol administration. A definite correlation was found between the degree of beta-adrenergic blockade, expressed as the reduction in maximal exercise heart rate and the change in mean arterial pressure. No relation could be shown between plasma propranolol steady state levels and these changes. The fall in blood pressure during beta-adrenergic blockade with a low dosage of propranolol apparently does not depend on changed baroreflex sensitivity, but on the intrinsic action of this drug on beta-receptors.
通过绘制脉博间期变化与去氧肾上腺素引起的收缩压短暂升高之间的关系曲线，对18例原发性高血压患者的压力感受器功能进行了测量。研究了普萘洛尔（每日160毫克，至少服用4周）对该功能以及最大运动后心率的影响，并将其与血浆普萘洛尔水平相关联。在18例患者中的13例中，服用普萘洛尔期间仅出现压力反射重调，而敏感性无变化。发现以最大运动心率降低表示的β-肾上腺素能阻滞程度与平均动脉压变化之间存在明确的相关性。血浆普萘洛尔稳态水平与这些变化之间未显示出相关性。低剂量普萘洛尔进行β-肾上腺素能阻滞期间的血压下降显然不取决于压力反射敏感性的改变，而是取决于该药物对β受体的内在作用。
