Ho S Y, Anderson R H
Br Heart J. 1979 Mar;41(3):268-74. doi: 10.1136/hrt.41.3.268.
A histological study has been made in an attempt to study further the relation between the ductus arteriosus, coarctation, and tubular hypoplasia of the aortic arch. Thirty-five aortic arch systems were studied using serial sectioning techniques. Twelve were from patients with coarctation and/or tubular hypoplasia. The other 23 hearts were from patients without aortic obstructive lesions, 7 from anatomically normal hearts, and the others from malformed hearts with anomalies elsewhere from the aortic arch. The anatomical study of the hearts with obstructive aortic lesions emphasised the necessity of distinguishing 'coarctation' from 'tubular hypoplasia', since the curtain lesion of coarctation was found to coexist with tubular hypoplasia in some cases. The histological study showed that the ductus was easily distinguished from the walls of the aorta or pulmonary artery. In all these cases with coarctation or tubular hypoplasia a sling of ductal tissue was located around the aortic isthmal orifice. In 6 hearts a diaphragm of ductal tissue was seen to form the coarctation lesion.
为了进一步研究动脉导管、主动脉缩窄与主动脉弓管状发育不全之间的关系，进行了一项组织学研究。使用连续切片技术对35个主动脉弓系统进行了研究。其中12个来自患有主动脉缩窄和/或管状发育不全的患者。另外23颗心脏来自没有主动脉阻塞性病变的患者，7颗来自解剖结构正常的心脏，其余来自主动脉弓以外部位有畸形的心脏。对患有主动脉阻塞性病变的心脏进行的解剖学研究强调了区分“主动脉缩窄”和“管状发育不全”的必要性，因为在某些情况下发现主动脉缩窄的帘状病变与管状发育不全并存。组织学研究表明，动脉导管很容易与主动脉或肺动脉壁区分开来。在所有这些患有主动脉缩窄或管状发育不全的病例中，导管组织带位于主动脉峡口周围。在6颗心脏中，可见导管组织隔膜形成主动脉缩窄病变。
