二氟尼柳在人体中的促尿酸排泄特性。
Uricosuric properties of diflunisal in man.
作者信息
Dresse A, Fischer P, Gerard M A, Tempero K F, Meisinger M A, Bolognese J A, Verhaest L
出版信息
Br J Clin Pharmacol. 1979 Mar;7(3):267-72. doi: 10.1111/j.1365-2125.1979.tb00931.x.
1 The uricosuric effect of diflunisal was studied in eleven normal subjects. 2 Urine and serum uric acid levels were measured and used to assess the effect. 3 Diflunisal caused statistically significant decreases in serum uric acid levels and increases in uric acid clearance at 250 and 375 mg twice daily. 4 Diflunisal taken on an empty stomach caused epigastric discomfort in the high dose group which was obviated when the drug was taken with meals. 5 Diflunisal caused no abnormalities in the measured haematological, urological or biochemical parameters.
在11名正常受试者中研究了二氟尼柳的促尿酸排泄作用。
测量尿液和血清尿酸水平并用于评估该作用。
二氟尼柳每日两次服用250毫克和375毫克时，可使血清尿酸水平有统计学意义的降低，并使尿酸清除率增加。
空腹服用二氟尼柳在高剂量组中引起上腹部不适，而与食物同服时这种不适可消除。
二氟尼柳在所测量的血液学、泌尿学或生化参数方面未引起异常。
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