人类小肠扁平（无绒毛）黏膜中的细胞周期时间。
The cell cycle time in the flat (avillous) mucosa of the human small intestine.
作者信息
Wright N, Watson A, Morley A, Appleton D, Marks J, Douglas A
出版信息
Gut. 1973 Aug;14(8):603-6. doi: 10.1136/gut.14.8.603.
Abstract
A hyperproductive mucosal state in gluten-sensitive enteropathy has been proposed on the basis of an elevated mitotic index, but this parameter is dependent on the mitotic duration when used as an index of proliferative status. The mitotic duration was therefore measured in two control patients with normal villous mucosae and in two patients with the flat avillous mucosa of untreated gluten-sensitive enteropathy, using two different stathmokinetic techniques with vincristine. No significant difference in mitotic duration was found but values obtained for cell cycle time showed a halving in the flat mucosae. An increased rate of cell production in the small bowel mucosa of untreated gluten-sensitive enteropathy is thus confirmed.
摘要
基于有丝分裂指数升高，有人提出麸质敏感性肠病存在黏膜高分泌状态，但该参数用作增殖状态指标时取决于有丝分裂持续时间。因此，使用两种不同的长春新碱有丝分裂阻断技术，对两名绒毛黏膜正常的对照患者和两名未经治疗的麸质敏感性肠病扁平无绒毛黏膜患者的有丝分裂持续时间进行了测量。未发现有丝分裂持续时间有显著差异，但细胞周期时间的值在扁平黏膜中减半。由此证实，未经治疗的麸质敏感性肠病患者小肠黏膜中的细胞生成率增加。
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本文引用的文献
1
CELL PROLIFERATION KINETICS IN THE GASTROINTESTINAL TRACT OF MAN. I. CELL RENEWAL IN COLON AND RECTUM.
J Clin Invest. 1963 Jun;42(6):767-76. doi: 10.1172/JCI104769.
2
Celiac disease. A study of the jejunal epithelium before and after a gluten-free diet.
N Engl J Med. 1962 Dec 6;267:1173-9. doi: 10.1056/NEJM196212062672303.
3
A morphologic and histochemical analysis of the human jejunal epithelium in nontropical sprue.
Gastroenterology. 1961 Jun;40:735-65.
4
Epithelial-cell renewal in cultured duodenal biopsies in celiac sprue.
N Engl J Med. 1970 Dec 3;283(23):1245-50. doi: 10.1056/NEJM197012032832302.
5
Enterocyte in coeliac disease. 1.
Br Med J. 1970 Sep 26;3(5725):725-31. doi: 10.1136/bmj.3.5725.725.
6
On correcting the error due to metaphase degeneration in stathmokinetic studies.
Exp Cell Res. 1972 Oct;74(2):496-502. doi: 10.1016/0014-4827(72)90406-5.
7
Variation in the duration of mitosis in the crypts of Lieberkuhn of the rat; a cytokinetic study using vincristine.
Cell Tissue Kinet. 1972 Jul;5(4):351-64. doi: 10.1111/j.1365-2184.1972.tb00374.x.
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