Barry R E, Morris J S, Read A E
Gut. 1970 Sep;11(9):743-7. doi: 10.1136/gut.11.9.743.
A patient is described with a severe malabsorption syndrome which failed to respond to a gluten-free diet. Although subtotal villous atrophy was present in the jejunal mucosa, histological features of subepithelial fibrosis and apparently normal enterocytes were not suggestive of coeliac disease. The findings of decreased mucosal thickness, of a normal mitotic rate in the crypt cell population, and of the decreased rate of loss of epithelial cells further suggested that the disease process producing the ;flat' mucosa was not that of coeliac disease. The condition was complicated by ileal ulceration and active tuberculosis.
本文描述了一名患有严重吸收不良综合征的患者，该患者对无麸质饮食无反应。尽管空肠黏膜存在绒毛部分萎缩，但上皮下纤维化和肠上皮细胞看似正常的组织学特征并不提示乳糜泻。黏膜厚度降低、隐窝细胞群有丝分裂率正常以及上皮细胞丢失率降低的结果进一步表明，导致“扁平”黏膜的疾病过程并非乳糜泻。该病症并发回肠溃疡和活动性肺结核。
