血浆未结合雌三醇与胱氨酸氨基肽酶浓度与子宫收缩之间的关系。

The relation between plasma unconjugated oestriol and cystine aminopeptidase concentrations and uterine contractions.

作者信息

Hull M G, Monro P P, Ellis B W

出版信息

Br J Obstet Gynaecol. 1979 Mar;86(3):180-5. doi: 10.1111/j.1471-0528.1979.tb10591.x.

DOI:10.1111/j.1471-0528.1979.tb10591.x

Abstract

The relation between maternal plasma unconjugated oestriol (E3) concentrations and uterine activity was investigated by very frequent, carefully timed determinations of E3 during synchronously recorded uterine contractions in six normal subjects. There was an initial rise (10 to 50 per cent above the mean) in E3 levels reaching a peak coincident with the contraction peak (range 20 seconds before to 15 seconds after) followed by a fall of similar magnitude below the mean reaching a nadir about 80 seconds (range 60 to 105 seconds) after the contraction peak. Although the pattern of E3 fluctuation was most marked in labour the overall degree of variation was no greater than at other times. Cystine aminopeptidase (CAP) concentrations in the same serum samples showed no significant correlation with uterine contractions. The reasons for, and practical applications of, the E3 results are discussed.

摘要

通过对六名正常受试者同步记录子宫收缩期间的未结合雌三醇（E3）进行非常频繁且定时精确的测定，研究了母体血浆中未结合雌三醇（E3）浓度与子宫活动之间的关系。E3水平最初会升高（高于平均值10%至50%），达到与收缩峰值同时出现的峰值（范围为收缩峰值前20秒至后15秒），随后下降至低于平均值的相似幅度，在收缩峰值后约80秒（范围为60至105秒）达到最低点。虽然E3波动模式在分娩时最为明显，但总体变化程度并不比其他时候更大。相同血清样本中的胱氨酸氨基肽酶（CAP）浓度与子宫收缩无显著相关性。文中讨论了E3结果的原因及实际应用。