Chovan J P, Kulakowski E C, Benson B W, Schaffer S W
Biochim Biophys Acta. 1979 Feb 20;551(1):129-35. doi: 10.1016/0005-2736(79)90359-6.
The effect of taurine on calcium binding to isolated rat heart sarcolemmal membrane was examined. Taurine was observed to increase calcium binding to the low affinity sites in both high sodium-low potassium and low sodium-high potassium buffers. Taurine was also seen to antagonize the inhibition of calcium binding to the sarcolemma caused by both verapamil and lanthanum. Nevertheless, membrane structural changes due to taurine could not be detected using the spin label ESR probe 2N14. A possible regulatory role of taurine is discussed.
研究了牛磺酸对钙与离体大鼠心肌肌膜结合的影响。观察到牛磺酸可增加在高钠低钾和低钠高钾缓冲液中钙与低亲和力位点的结合。还发现牛磺酸可拮抗维拉帕米和镧对钙与肌膜结合的抑制作用。然而，使用自旋标记ESR探针2N14未检测到牛磺酸引起的膜结构变化。讨论了牛磺酸可能的调节作用。
