男性淋菌性尿道炎的单剂量治疗：普鲁卡因青霉素、氨苄青霉素和壮观霉素的评估。
Single-dose treatment of gonococcal urethritis in males: evaluation of procaine penicillin, ampicillin and spectinomycin.
作者信息
Mitchell R W, Robson H G
出版信息
Can Med Assoc J. 1974 Jan 19;110(2):165-7.
Males with acute gonococcal urethritis were treated at random with 2.4 million units aqueous procaine penicillin G intramuscularly plus 1.0 g. probenecid orally, 3.5 g. ampicillin orally plus 1.0 g. probenecid orally, or 2.0 g. spectinomycin intramuscularly. The overall follow-up was 97%. All treatments were of equal efficacy, eradication of gonococcal disease being observed in 93 to 97% of treated patients. Treatment failures occurred in each drug group and pre-treatment isolates recovered from these cases showed decreased susceptibility to the agent used. Aqueous procaine penicillin G plus probenecid remains the preferred therapy for gonorrhea. For patients hypersensitive to penicillin, spectinomycin is currently a reasonable alternative drug. This agent, unlike procaine penicillin-probenecid, is probably ineffective against concurrent incubating syphilis, and future development of bacterial resistance is a definite possibility.
患有急性淋菌性尿道炎的男性患者被随机分为三组接受治疗
第一组肌肉注射240万单位的普鲁卡因青霉素G水剂加口服1.0克丙磺舒；第二组口服3.5克氨苄青霉素加口服1.0克丙磺舒；第三组肌肉注射2.0克壮观霉素。总体随访率为97%。所有治疗方法疗效相当，在93%至97%的接受治疗的患者中观察到淋菌性疾病被根除。每个药物组均出现了治疗失败的情况，从这些病例中分离出的治疗前菌株对所用药物的敏感性降低。普鲁卡因青霉素G水剂加丙磺舒仍然是淋病的首选治疗方法。对于对青霉素过敏的患者，壮观霉素目前是一种合理的替代药物。与普鲁卡因青霉素-丙磺舒不同，这种药物可能对同时潜伏的梅毒无效，而且细菌产生耐药性的情况在未来肯定有可能发生。
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