用盐酸大观霉素治疗淋菌性尿道炎。

Treatment of gonorrheal urethritis with spectinomycin hydrochloride.

作者信息

Brown J, Tabert O, Hanna J D, Rentiers P L

出版信息

Can Med Assoc J. 1974 Jan 19;110(2):173 passim.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1947120/

Abstract

One hundred and eighty-seven males with uncomplicated gonorrheal urethritis were treated with spectinomycin hydrochloride in a dosage of 2 g. given intramuscularly. A failure rate of 3.2% was observed and no complications of therapy were encountered. In addition, 310 strains of N. gonorrhoeae were tested for susceptibility to penicillin G and spectinomycin. All strains were sensitive to 20 mug./ml. of spectinomycin and this susceptibility appeared to decrease as penicillin resistance increased. A greater incidence of relative resistance to penicillin G was observed than in similar studies from other Canadian areas.

摘要

187例单纯性淋病性尿道炎男性患者接受了2g盐酸大观霉素肌肉注射治疗。观察到治疗失败率为3.2%，且未出现治疗并发症。此外，对310株淋病奈瑟菌进行了青霉素G和大观霉素敏感性测试。所有菌株对20μg/ml大观霉素敏感，且随着青霉素耐药性增加，这种敏感性似乎降低。与加拿大其他地区的类似研究相比，观察到对青霉素G相对耐药的发生率更高。

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