通过移植胎胰控制大鼠实验性糖尿病
Control of experimental diabetes mellitus in rats by transplantation of fetal pancreases.
作者信息
Brown J, Molnar I G, Clark W, Mullen Y
出版信息
Science. 1974 Jun 28;184(4144):1377-9. doi: 10.1126/science.184.4144.1377.
PMID:4275321
Abstract
Experimental diabetes mellitus in young adult Lewis rats was successfully treated by transplantation of fetal pancreases from syngeneic fetuses. Complete or partial control lasting up to 165 days was achieved in 64 percent of recipients by using two to three pancreases of fetal age (15 to 18(1/2) days) placed under each kidney capsule. Islets of Langerhans without exocrine elements were present in the transplants.
摘要
通过移植同基因胎儿的胰腺，成功治疗了成年幼龄Lewis大鼠的实验性糖尿病。在每个肾囊下植入两到三个胎龄（15至18（1/2）天）的胰腺，64%的受体实现了长达165天的完全或部分血糖控制。移植的胰腺中存在无外分泌成分的胰岛。
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