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Further study on neutralization of biochemical activity of cord factor by anti-cord factor antibody.抗索状因子抗体对索状因子生化活性中和作用的进一步研究。
Infect Immun. 1974 Jul;10(1):277-9. doi: 10.1128/iai.10.1.277-279.1974.
2
Site II-specific inhibition of mitochondria oxidative phosphorylation by trehalose-6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis.结核分枝杆菌的海藻糖-6,6'-二霉菌酸酯（索状因子）对线粒体氧化磷酸化的II型位点特异性抑制作用。
Arch Biochem Biophys. 1970 Oct;140(2):379-90. doi: 10.1016/0003-9861(70)90079-2.
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Chemical structure and biochemical activity of cord factor analogs. 6,6'-Dimycoloyl sucrose and methyl 6-mycoloyl- -D-glucoside.
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[Mechanism of action of cord factor (trehalose-6,6'-dimycolate) of Mycobacterium tuberculosis].
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Infect Immun. 1974 Jan;9(1):8-14. doi: 10.1128/iai.9.1.8-14.1974.

引用本文的文献

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Cell walls of Mycobacteria and related organisms; chemistry and immunostimulant properties.分枝杆菌及相关生物体的细胞壁；化学性质与免疫刺激特性
Mol Cell Biochem. 1975 May 30;7(2):87-104. doi: 10.1007/BF01792076.
2
Mycobacterium.分枝杆菌属
Bacteriol Rev. 1977 Mar;41(1):217-372. doi: 10.1128/br.41.1.217-372.1977.

本文引用的文献

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The serum proteins in multiple myelomatosis.多发性骨髓瘤中的血清蛋白
Biochem J. 1940 Sep;34(8-9):1248-57. doi: 10.1042/bj0341248.
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Studies on the chemistry of the cord factor of Mycobacterium tuberculosis.结核分枝杆菌索状因子的化学研究。
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3
Studies of a biochemical lesion in experimental tuberculosis in mice. 8. Effect of derivatives and chemical analogues of cord factor on structure and function of mouse liver mitochondria.
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Studies of a biochemical lesion in experimental tuberculosis in mice. VII. Structural and functional damage in mouse liver mitochondria under the toxic action of cord factor.
Am Rev Respir Dis. 1968 Aug;98(2):260-9. doi: 10.1164/arrd.1968.98.2.260.
5
Chemical structure and biochemical activity of cord factor analogs. 6,6'-Dimycoloyl sucrose and methyl 6-mycoloyl- -D-glucoside.
Eur J Biochem. 1971 Oct 14;22(3):364-70. doi: 10.1111/j.1432-1033.1971.tb01553.x.
6
Site II-specific inhibition of mitochondria oxidative phosphorylation by trehalose-6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis.结核分枝杆菌的海藻糖-6,6'-二霉菌酸酯（索状因子）对线粒体氧化磷酸化的II型位点特异性抑制作用。
Arch Biochem Biophys. 1970 Oct;140(2):379-90. doi: 10.1016/0003-9861(70)90079-2.
7
Isolation and biochemical activities of trehalose-6-monomycolate of Mycobacterium tuberculosis.
Infect Immun. 1974 Jan;9(1):8-14. doi: 10.1128/iai.9.1.8-14.1974.
8
Site of action of lipid A on mitochondria.脂多糖A在线粒体上的作用位点。
J Bacteriol. 1972 Oct;112(1):268-75. doi: 10.1128/jb.112.1.268-275.1972.

抗索状因子抗体对索状因子生化活性中和作用的进一步研究。

Further study on neutralization of biochemical activity of cord factor by anti-cord factor antibody.

作者信息

Kato M

出版信息

Infect Immun. 1974 Jul;10(1):277-9. doi: 10.1128/iai.10.1.277-279.1974.

DOI:10.1128/iai.10.1.277-279.1974
PMID:4276350
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414989/
Abstract

The action of trehalose-6, 6'-dimycolate (cord factor) of Mycobacterium tuberculosis to induce site II-specific inhibition of mitochondrial oxidative phosphorylation and to stimulate adenosine triphosphatase activity was neutralized by its specific antibody. The activity was restored after dissociation of cord factor from the immune complex.

摘要

结核分枝杆菌的海藻糖-6,6'-二甲酯（索状因子）诱导线粒体氧化磷酸化的II位点特异性抑制并刺激三磷酸腺苷酶活性的作用被其特异性抗体中和。索状因子从免疫复合物解离后，活性得以恢复。