犬肾髓质高度纯化的钠钾ATP酶抗体的作用：“全酶抗体”分离为催化性和强心苷受体特异性成分。
Effects of an antibody to a highly purified Na+, K+-ATPase from canine renal medulla: separation of the "holoenzyme antibody" into catalytic and cardiac glycoside receptor-specific components.
作者信息
McCans J L, Lane L K, Lindenmayer G E, Butler V P, Schwartz A
出版信息
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2449-52. doi: 10.1073/pnas.71.6.2449.
Abstract
An antiserum was prepared against a highly purified Na(+), K(+)-adenosine triphosphatase (ATP phosphohydrolase, EC 3.6.1.3). Purification and fractionation yielded two globulin components, one of which appears specific for a digitalis glycoside receptor site or binding conformation and the other for a catalytic site or conformation.
摘要
制备了一种针对高度纯化的钠钾腺苷三磷酸酶（ATP磷酸水解酶，EC 3.6.1.3）的抗血清。纯化和分级分离产生了两种球蛋白成分，其中一种似乎对洋地黄糖苷受体位点或结合构象具有特异性，另一种对催化位点或构象具有特异性。
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Effects of an antibody to a highly purified Na+, K+-ATPase from canine renal medulla: separation of the "holoenzyme antibody" into catalytic and cardiac glycoside receptor-specific components.犬肾髓质高度纯化的钠钾ATP酶抗体的作用：“全酶抗体”分离为催化性和强心苷受体特异性成分。
Proc Natl Acad Sci U S A. 1974 Jun;71(6):2449-52. doi: 10.1073/pnas.71.6.2449.
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Z Naturforsch B. 1969 Jun;24(6):693-8.
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Antibodies to pig kidney (Na + +K + )-ATPase inhibit the Na + pump in human red cells provided they have access to the inner surface of the cell membrane.针对猪肾（Na⁺+K⁺）-ATP酶的抗体，只要能接触到细胞膜内表面，就能抑制人红细胞中的钠泵。
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J Pharmacol Exp Ther. 1969 Jul;168(1):31-41.
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Tritiated digoxin binding to (Na+ + K+)-activated adenosine triphosphatase: possible allosteric site.氚标记地高辛与（钠+钾）激活的三磷酸腺苷酶的结合：可能的别构位点。
Science. 1968 Apr 19;160(3825):323-5. doi: 10.1126/science.160.3825.323.
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