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New ribonucleotide reductase inhibitors with antineoplastic activity.

作者信息

Elford H L, Wampler G L, van't Riet B

出版信息

Cancer Res. 1979 Mar;39(3):844-51.

PMID:427774
Abstract
摘要

相似文献

1
New ribonucleotide reductase inhibitors with antineoplastic activity.
Cancer Res. 1979 Mar;39(3):844-51.
2
Characterization of mouse leukemia L1210 cells resistant to the ribonucleotide reductase inhibitor 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone.对核糖核苷酸还原酶抑制剂4-甲基-5-氨基-1-甲酰基异喹啉硫代半卡巴腙耐药的小鼠白血病L1210细胞的特性分析
Oncol Res. 1996;8(10-11):449-56.
3
Leukemia L1210 cell lines resistant to ribonucleotide reductase inhibitors.对核糖核苷酸还原酶抑制剂耐药的白血病L1210细胞系。
Cancer Res. 1988 Feb 15;48(4):839-43.
4
Synthesis of hydroxy- and amino-substituted benzohydroxamic acids: inhibition of ribonucleotide reductase and antitumor activity.
J Med Chem. 1979 May;22(5):589-92. doi: 10.1021/jm00191a027.
5
Studies on the mechanisms of inhibition of L1210 cell growth by 3,4-dihydroxybenzohydroxamic acid and 3,4-dihydroxybenzamidoxime.3,4-二羟基苯氧肟酸和3,4-二羟基苯甲脒肟对L1210细胞生长抑制机制的研究
Adv Enzyme Regul. 1991;31:71-83. doi: 10.1016/0065-2571(91)90009-b.
6
Cross-resistance patterns in hydroxyurea-resistant leukemia L1210 cells.羟基脲耐药白血病L1210细胞中的交叉耐药模式。
Cancer Res. 1988 Oct 15;48(20):5796-9.
7
Regulation of ribonucleotide reductase in mammalian cells by chemotherapeutic agents.化疗药物对哺乳动物细胞中核糖核苷酸还原酶的调控。
Adv Enzyme Regul. 1980;19:151-68. doi: 10.1016/0065-2571(81)90014-5.
8
Potentiation of the activity of cisplatin and cyclophosphamide by trimidox, a novel ribonucleotide reductase inhibitor, in leukemia-bearing mice.新型核糖核苷酸还原酶抑制剂三甲曲沙增强顺铂和环磷酰胺对荷白血病小鼠的活性。
Cancer Lett. 2006 Feb 20;233(1):178-84. doi: 10.1016/j.canlet.2005.03.013.
9
DNA-protective activity of new ribonucleotide reductase inhibitors.新型核糖核苷酸还原酶抑制剂的DNA保护活性
Anticancer Res. 1997 Sep-Oct;17(5A):3437-40.
10
Understanding the antitumor activity of novel hydroxysemicarbazide derivatives as ribonucleotide reductase inhibitors using CoMFA and CoMSIA.
J Med Chem. 2003 Oct 9;46(21):4419-27. doi: 10.1021/jm030016a.

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Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer.核糖核苷酸还原酶M2（RRM2）：人类癌症中的调控、功能及靶向策略
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Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present.癌症靶点核糖核苷酸还原酶的抑制剂，过去与现在
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The Antitumor Didox Acts as an Iron Chelator in Hepatocellular Carcinoma Cells.抗肿瘤药物Didox在肝癌细胞中作为铁螯合剂发挥作用。
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Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription.双多西（3,4-二羟基苯甲异羟肟酸）通过减弱核因子κB和活化蛋白-1转录来抑制免疫球蛋白E介导的肥大细胞活化。
Cell Immunol. 2017 Dec;322:41-48. doi: 10.1016/j.cellimm.2017.09.008. Epub 2017 Sep 21.
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Clinical pharmacology and clinical trials of ribonucleotide reductase inhibitors: is it a viable cancer therapy?核糖核苷酸还原酶抑制剂的临床药理学与临床试验：它是一种可行的癌症治疗方法吗？
J Cancer Res Clin Oncol. 2017 Aug;143(8):1499-1529. doi: 10.1007/s00432-017-2457-8. Epub 2017 Jun 17.
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Didox and resveratrol sensitize colorectal cancer cells to doxorubicin via activating apoptosis and ameliorating P-glycoprotein activity.地卓西平和白藜芦醇通过激活细胞凋亡和改善 P-糖蛋白活性使结直肠癌细胞对阿霉素敏感。
Sci Rep. 2016 Nov 14;6:36855. doi: 10.1038/srep36855.
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3,4-Dihydroxy-benzohydroxamic acid (Didox) suppresses pro-inflammatory profiles and oxidative stress in TLR4-activated RAW264.7 murine macrophages.3,4-二羟基苯甲异羟肟酸（Didox）抑制TLR4激活的RAW264.7小鼠巨噬细胞中的促炎特征和氧化应激。
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The efficacy of the ribonucleotide reductase inhibitor Didox in preclinical models of AML.核糖核苷酸还原酶抑制剂Didox在急性髓系白血病临床前模型中的疗效。
PLoS One. 2014 Nov 17;9(11):e112619. doi: 10.1371/journal.pone.0112619. eCollection 2014.