Zaitoun A M, Lauder I, Aherne W A
Cell Tissue Kinet. 1979 Mar;12(2):191-201. doi: 10.1111/j.1365-2184.1979.tb00125.x.
The cell population kinetic parameters of the thymus in BALB/c mice have been estimated using stathmokinetic and [3H]TdR techniques in both control animals and animals treated with prednisolone. FLM data were analysed by computer using the Gilbert program. The study showed that prednisolone had an inhibitory effect mainly in the DNA synthesis phase and in G1. Stathmokinetic data also showed a decrease in the cell birth rate and an increase in the apparent cell cycle time (or potential doubling time) after treatment. The labelling index, the mitotic index and the growth fraction were also decreased. The study also shows a good agreement between the data obtained by stathmokinetic and [3H]TdR techniques.
在对照动物和用泼尼松龙处理的动物中，已使用有丝分裂动力学和[3H]TdR技术估计了BALB/c小鼠胸腺的细胞群体动力学参数。使用吉尔伯特程序通过计算机分析FLM数据。研究表明，泼尼松龙主要在DNA合成期和G1期具有抑制作用。有丝分裂动力学数据还显示，处理后细胞出生率降低，表观细胞周期时间（或潜在倍增时间）增加。标记指数、有丝分裂指数和生长分数也降低。该研究还表明，通过有丝分裂动力学和[3H]TdR技术获得的数据之间具有良好的一致性。
