地高辛在人心脏中的生理分布。
Physiological distribution of digoxin in human heart.
作者信息
Coltart D J, Güllner H G, Billingham M, Goldman R H, Stinson E B, Kalman S M, Harrison D C
出版信息
Br Med J. 1974 Dec 28;4(5947):733-6. doi: 10.1136/bmj.4.5947.733.
Abstract
Using the recipient's human heart removed at cardiac transplantation, the distribution of digoxin at both the cellular and subcellular level has been studied. In the presence of diffuse histological myocardial abnormalities tissue digoxin is decreased, but the subcellular distribution, presumably reflecting binding to a possible receptor site, is uniform. When the histological abnormality is focal then digoxin distribution is uniform.These results suggest that in the presence of myocardial ischaemia plasma digoxin concentrations may not reflect total myocardial levels accurately.
摘要
利用心脏移植时取出的受者心脏，研究了地高辛在细胞和亚细胞水平的分布情况。在存在弥漫性组织学心肌异常的情况下，组织中的地高辛含量降低，但亚细胞分布（推测反映了与可能的受体部位的结合）是均匀的。当组织学异常为局灶性时，地高辛分布也是均匀的。这些结果表明，在存在心肌缺血的情况下，血浆地高辛浓度可能无法准确反映心肌总水平。
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本文引用的文献
1
The distribution and concentration of tritiated digoxin in human tissues.
Ann Intern Med. 1967 Jan;66(1):116-24. doi: 10.7326/0003-4819-66-1-116.
2
Double isotope dilution derivative assay of digitoxin in plasma, urine, and stool of patients maintained on the drug.
J Clin Invest. 1966 May;45(5):782-95. doi: 10.1172/JCI105393.
3
An improved method for measuring plasma and tissue concentrations of digitalis glycosides.
J Lab Clin Med. 1966 Jun;67(6):1048-52.
4
Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay.
N Engl J Med. 1969 Nov 27;281(22):1212-6. doi: 10.1056/NEJM196911272812203.
5
Altered distribution of tritiated digoxin in the infarcted canine left ventricle.
Circulation. 1972 Sep;46(3):572-9. doi: 10.1161/01.cir.46.3.572.
6
Cardiac transplantation in man. 3. Surgical aspects.
Am J Surg. 1969 Aug;118(2):182-7. doi: 10.1016/0002-9610(69)90118-4.
7
Cardiac transplantation in man. Review of first three years' experience.
Am J Med. 1973 May;54(5):563-76. doi: 10.1016/0002-9343(73)90114-9.
8
The inotropic effects of digoxin in hyperkalemia. Relation to (Na+,K+)-ATPase inhibition in the intact animal.
Circulation. 1973 Oct;48(4):830-8. doi: 10.1161/01.cir.48.4.830.
9
(Na+,K+)-ATPase activity in a preparation from human post-mortem myocardium.
Cardiovasc Res. 1970 Apr;4(2):201-6. doi: 10.1093/cvr/4.2.201.
10
Correlation of cardiac sodium- and potassium-activated adenosine triphosphatase activity with ouabain-induced inotropic stimulation.
J Pharmacol Exp Ther. 1970 May;173(1):145-51.
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