A gas chromatographic method for determining haloperidol. A sensitive procedure for studying serum concentration and pharmacokinetics of haloperidol in patients.

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作者信息

Forsman A, Mårtensson E, Nyberg G, Ohman R

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1974;286(2):113-24. doi: 10.1007/BF00501606.

DOI:10.1007/BF00501606

PMID:4281877

Abstract

摘要

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A gas chromatographic method for determining haloperidol. A sensitive procedure for studying serum concentration and pharmacokinetics of haloperidol in patients.

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Haloperidol determination in serum and cerebrospinal fluid using gas--liquid chromatography with nitrogen--phosphorus detection: application to pharmacokinetic studies.采用带氮磷检测的气液色谱法测定血清和脑脊液中的氟哌啶醇：在药代动力学研究中的应用

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Simultaneous determination of haloperidol and its reduced metabolite in serum and plasma by isocratic liquid chromatography with electrochemical detection.采用等度液相色谱-电化学检测法同时测定血清和血浆中的氟哌啶醇及其还原代谢物。

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Distribution, excretion and metabolism of neuroleptics of the butyrophenone type. I. Excretion and metabolism of haloperidol and nine related butyrophenone-derivatives in the Wistar rat.丁酰苯类抗精神病药物的分布、排泄及代谢。I. 氟哌啶醇及九种相关丁酰苯衍生物在Wistar大鼠体内的排泄与代谢

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Development and Evaluation of a Physiologically Based Pharmacokinetic Model for Predicting Haloperidol Exposure in Healthy and Disease Populations.用于预测健康人群和疾病人群中氟哌啶醇暴露量的基于生理的药代动力学模型的开发与评估

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Pharmacokinetics of haloperidol: an update.氟哌啶醇的药代动力学：最新进展。

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A long-term cross-over pharmacokinetic study comparing perphenazine decanoate and haloperidol decanoate in schizophrenic patients.一项在精神分裂症患者中比较癸酸奋乃静和癸酸氟哌啶醇的长期交叉药代动力学研究。

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Pharmacokinetics of haloperidol in psychotic patients.氟哌啶醇在精神病患者中的药代动力学。

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Antipsychotic drugs. Clinical pharmacokinetics of potential candidates for plasma concentration monitoring.抗精神病药物。血浆浓度监测潜在候选药物的临床药代动力学。

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Substantial rise in sparteine metabolic ratio during haloperidol treatment.在氟哌啶醇治疗期间，鹰爪豆碱代谢率大幅上升。

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Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of some butyrophenones.用Sep-Pak C18柱快速分离及宽口径毛细管气相色谱法分析某些丁酰苯类化合物

Z Rechtsmed. 1989;102(2-3):127-32. doi: 10.1007/BF00200506.

Individual variability in response to haloperidol.个体对氟哌啶醇反应的变异性。

Proc R Soc Med. 1976;69 suppl 1(Suppl 1):9-12. doi: 10.1177/00359157760690S103.

本文引用的文献

[Cardiovascular actions of Haloperidol].

Arch Int Pharmacodyn Ther. 1962 May 1;137:91-107.

Neurolept-analgesia--an alternative to general anaesthesia.神经安定镇痛术——全身麻醉的一种替代方法。

Acta Anaesthesiol Scand. 1961;5:73-84. doi: 10.1111/j.1399-6576.1961.tb00085.x.

Circulatory response to tilt with some anti-emetic and sedative drugs.某些止吐药和镇静药对倾斜的循环反应。

Can Anaesth Soc J. 1961 Jul;8:387-93. doi: 10.1007/BF03021357.

A gas chromatographic method for the determination of haloperidol in human plasma.一种测定人血浆中氟哌啶醇的气相色谱法。

J Chromatogr. 1971 Jan 6;54(1):15-24. doi: 10.1016/s0021-9673(01)80240-5.

Receptor activity and turnover of dopamine and noradrenaline after neuroleptics.抗精神病药物治疗后多巴胺和去甲肾上腺素的受体活性及更新率

Eur J Pharmacol. 1970;11(3):303-14. doi: 10.1016/0014-2999(70)90006-3.

Steady-state plasma levels of nortriptyline in twins: influence of genetic factors and drug therapy.双胞胎中去甲替林的稳态血浆水平：遗传因素和药物治疗的影响。

Br Med J. 1969 Dec 27;4(5686):764-8. doi: 10.1136/bmj.4.5686.764.

[Intoxications by butyrophenones].[丁酰苯类中毒]

Eur J Toxicol. 1971 Sep-Oct;4(5):385-402.

[Chromatographic analysis of some butyrophenones of pharmaceutical use].[药用丁酰苯类化合物的色谱分析]

Boll Chim Farm. 1971 Jul;110(7):385-92.

A method for the gas chromatographic determination of butyrophenones.一种气相色谱法测定丁酰苯类化合物的方法。

J Chromatogr. 1971 Jul 8;59(1):174-7. doi: 10.1016/s0021-9673(01)80021-2.

Central monoamine metabolism in man. Effect of putative dopamine receptor agonists and antagonists.人类中枢单胺代谢。假定的多巴胺受体激动剂和拮抗剂的作用。

Arch Neurol. 1973 Nov;29(5):349-51. doi: 10.1001/archneur.1973.00490290089014.

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