Chang M C, Saksena S K, Lau I F, Wang Y H
Contraception. 1979 Feb;19(2):175-84. doi: 10.1016/s0010-7824(79)80029-3.
Trichosanthin, a protein purified from the extract of the root tuber of Trichosanthis Kirilowii, Maxim, given once only induced midterm abortion in the mice and rabbits. The effective I.P. dose for the induction of abortion in 10- or 11-day pregnant mouse was 50 micrograms. In the rabbit a dose and state of pregnancy-dependent response to Trichosanthin-induced abortion was encountered. A dose as low as 0.5 mg Trichosanthin in 22-day pregnant rabbit was adequate but 2.0 mg was needed in 17-day pregnant rabbit. Attempts to terminate pregnancy in the rat and hamster using Trichosanthin was not successful even with higher doses. When compared with prostaglandin-F2 alpha, an established abortifacient, Trichosanthin appeared to be more effective and associated with less side effects in the induction of abortion in the rabbit. Trichosanthin was ineffective to terminate early pregnancy in the 4 species studied.
天花粉蛋白是从瓜蒌（Trichosanthis Kirilowii，Maxim）块根提取物中纯化得到的一种蛋白质，单次给药即可诱导小鼠和家兔中期流产。对10或11日龄怀孕小鼠诱导流产的有效腹腔注射剂量为50微克。在家兔中，观察到对天花粉蛋白诱导流产的剂量和妊娠状态依赖性反应。在22日龄怀孕家兔中，低至0.5毫克的天花粉蛋白剂量就足够了，但在17日龄怀孕家兔中则需要2.0毫克。即使使用更高剂量的天花粉蛋白，尝试在大鼠和仓鼠中终止妊娠也未成功。与已确定的堕胎药前列腺素F2α相比，天花粉蛋白在诱导家兔流产方面似乎更有效且副作用更少。在所研究的4个物种中，天花粉蛋白对终止早期妊娠无效。
