Bemm H, Lohmann D
Allerg Immunol (Leipz). 1974;20-21(1):15-20.
164 patients, who required clinical treatment because of newly diagnosed diabetes mellitus or known and metabolically disordered diabetes mellitus, were examined for insulin antibody activities. The results of antibody determinations in serum are compared with late diabetic complications. The time of treatment with insulin and the duration of diabetes were found to be closely correlated with the development of organic complications and insulin antibodies. The symptoms of the late diabetic syndrome are considered to be consequences of an immunological process. Due to the variability of the development of insulin antibodies and late diabetic complications the individual immunological manner of reaction of the organism different antibody properties, and nonspecific immunological processes may be of decisive importance to the clinical development.
164例因新诊断的糖尿病或已知的代谢紊乱性糖尿病而需要临床治疗的患者接受了胰岛素抗体活性检测。将血清中抗体测定结果与糖尿病晚期并发症进行比较。发现胰岛素治疗时间和糖尿病病程与器质性并发症及胰岛素抗体的发生密切相关。糖尿病晚期综合征的症状被认为是免疫过程的结果。由于胰岛素抗体和糖尿病晚期并发症发展的变异性，机体不同抗体特性的个体免疫反应方式以及非特异性免疫过程可能对临床发展起决定性作用。
