Waldmeier P C, Feldtrauer J J, Kam R, Stöcklin K
Eur J Pharmacol. 1979 Mar 1;54(3):279-87. doi: 10.1016/0014-2999(79)90087-6.
In rats, baclofen injected unilaterally into the substantia nigra increased dopamine (DA) and serotonin (5-HT) levels in the ipsilateral striata. Homovanillic acid levels first decreased and then increased to a maximum after 4 h. The content of 3,4-dihydroxyphenylacetic acid also increased after a latency of about 1 h. The effects of baclofen on striatal DA metabolism are consistent with the assumption that impulse flow in these DA neurones was diminshed by the drug. DA metabolites were also found in greater quantities in the contralateral striata, probably owing to compensatory activation of these DA neurones. Baclofen injected intranigrally did not increase the striatal 5-HT content in rats with a 6-hydroxydopamine-induced lesion of the nigrostriatal DA pathway. Our results suggest the presence of DA receptors on striatal 5-HT terminals or on interneurones synapsing axo-axonally with them.
在大鼠中，单侧注射巴氯芬至黑质可使同侧纹状体中的多巴胺（DA）和5-羟色胺（5-HT）水平升高。高香草酸水平先下降，4小时后升至最高值。3,4-二羟基苯乙酸的含量在约1小时的潜伏期后也增加。巴氯芬对纹状体DA代谢的影响与以下假设一致：该药物使这些DA神经元中的冲动流减少。在对侧纹状体中也发现了更多的DA代谢物，这可能是由于这些DA神经元的代偿性激活。在6-羟基多巴胺诱导黑质纹状体DA通路损伤的大鼠中，经黑质内注射巴氯芬不会增加纹状体5-HT含量。我们的结果提示在纹状体5-HT终末或与它们轴-轴突触的中间神经元上存在DA受体。
