Kouyoumdjiian J C, Gonnard P, Belin M F
Naunyn Schmiedebergs Arch Pharmacol. 1979 Oct;309(1):7-11. doi: 10.1007/BF00498750.
Fenfluramine has been considered to deplete neuronal 5-hydroxytryptamine (5-HT). This compound is able to reduce the synaptosomal uptake of 5-HT and other neurotransmitters such as GABA and glutamic acid (Glu). The effects of fenfluramine on these three compounds considered as neurotransmitters are different. The inhibition is of competitive type for 5-HT and non-competitive for GABA and Glu. Concerning the enzymes involved in GABA synthesis and degradation, Fenfluramine increases Glutamic acid decarboxylase activity and decreases GABA-trasaminase activity in synaptosomes. Decreased synaptosomal GABA levels could be attributed to a lower uptake. An enzymatic regulating system may be responsible in restoring the GABA level. A similar mechanism concerning serotonin has been previously suggested (Costa et al., 1971).
芬氟拉明被认为会消耗神经元中的5-羟色胺（5-HT）。这种化合物能够减少突触体对5-HT以及其他神经递质如γ-氨基丁酸（GABA）和谷氨酸（Glu）的摄取。芬氟拉明对这三种被视为神经递质的化合物的作用有所不同。其对5-HT的抑制是竞争性的，而对GABA和Glu的抑制是非竞争性的。关于参与GABA合成和降解的酶，芬氟拉明会增加突触体中谷氨酸脱羧酶的活性，并降低GABA转氨酶的活性。突触体GABA水平的降低可能归因于摄取减少。一种酶调节系统可能负责恢复GABA水平。先前已有人提出关于血清素的类似机制（科斯塔等人，1971年）。
