文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Raghuramulu N, Srikantia S G, Rao B S, Gopalan C

Biochem J. 1965 Sep;96(3):837-9. doi: 10.1042/bj0960837.

The nicotinamide nucleotide concentrations in the erythrocytes of subjects suffering from pellagra (pellagrins) were not lower than those in normal subjects, but the ability of erythrocytes to synthesize these nucleotides in vitro was significantly lower in pellagrins. 2. The oral administration of 10g. of l-leucine daily for 5 days depressed the nicotinamide nucleotide-synthesizing ability of erythrocytes both in normal subjects and in pellagrins. This was not accompanied by changes in the nucleotide concentration in erythrocytes. 3. Quinolinic acid brought about a significant inhibition of the synthesis of nicotinamide nucleotides in vitro. Such inhibition was partially overcome by increasing the concentration of nicotinic acid in the medium.

患有糙皮病的受试者（糙皮病患者）红细胞中的烟酰胺核苷酸浓度并不低于正常受试者，但糙皮病患者红细胞在体外合成这些核苷酸的能力显著较低。2. 正常受试者和糙皮病患者每天口服10克L-亮氨酸，持续5天，均会降低红细胞烟酰胺核苷酸的合成能力。这并未伴随红细胞中核苷酸浓度的变化。3. 喹啉酸在体外对烟酰胺核苷酸的合成产生显著抑制作用。通过增加培养基中烟酸的浓度，这种抑制作用可部分得到克服。

Raghuramulu N, Srikantia S G, Rao B S, Gopalan C

Biochem J. 1965 Sep;96(3):837-9. doi: 10.1042/bj0960837.

The nicotinamide nucleotide concentrations in the erythrocytes of subjects suffering from pellagra (pellagrins) were not lower than those in normal subjects, but the ability of erythrocytes to synthesize these nucleotides in vitro was significantly lower in pellagrins. 2. The oral administration of 10g. of l-leucine daily for 5 days depressed the nicotinamide nucleotide-synthesizing ability of erythrocytes both in normal subjects and in pellagrins. This was not accompanied by changes in the nucleotide concentration in erythrocytes. 3. Quinolinic acid brought about a significant inhibition of the synthesis of nicotinamide nucleotides in vitro. Such inhibition was partially overcome by increasing the concentration of nicotinic acid in the medium.

患有糙皮病的受试者（糙皮病患者）红细胞中的烟酰胺核苷酸浓度并不低于正常受试者，但糙皮病患者红细胞在体外合成这些核苷酸的能力显著较低。2. 正常受试者和糙皮病患者每天口服10克L-亮氨酸，持续5天，均会降低红细胞烟酰胺核苷酸的合成能力。这并未伴随红细胞中核苷酸浓度的变化。3. 喹啉酸在体外对烟酰胺核苷酸的合成产生显著抑制作用。通过增加培养基中烟酸的浓度，这种抑制作用可部分得到克服。