Nisticó G, Germanà G, Ciriaco E, Bronzetti B, Rotiroti D, Scapagnini U
Neuroendocrinology. 1979;29(6):418-25. doi: 10.1159/000122953.
Present experiments were aimed at studying in pigeons the effects of some neuroleptic agents given systemically or into the 3rd cerebral ventricle on PRL secretion and following morphological changes of the crop-sac mucosa both by classical histological methods and scanning electron microscopy. In addition, such changes were also evaluated on the basis of a semiquantitative method using a 1-4 rating scale. 3- or 5-day systemic treatment with reserpine, haloperidol and (ł/-)-sulpiride produced an intense crop-sac response consisting of a marked epithelial hyperplasia and presence of milk-like material. Similarly, a much lower dose of haloperidol, clozapine, and the two enantiomers of sulpiride given into the 3rd cerebral ventricle for 3 consecutive days produced a marked crop-sac response. The l-sulpiride was more active in comparison to the d-enantiomer. In conclusion, present experiments show that, similarly to mammals, in pigeons neuroleptic drugs are able to stimulate prolactin secretion and suggest that these effects are mediated through an action at the hypothalamic and/or pituitary level by removing a tonic dopaminergic inhibition.
目前的实验旨在通过经典组织学方法和扫描电子显微镜，研究给鸽子全身或第三脑室注射某些抗精神病药物对催乳素分泌以及随后嗉囊黏膜形态变化的影响。此外，还基于使用1 - 4评分量表的半定量方法对这些变化进行了评估。用利血平、氟哌啶醇和（左旋）舒必利进行3天或5天的全身治疗产生了强烈的嗉囊反应，包括明显的上皮增生和出现乳状物质。同样，连续3天向第三脑室注射低得多剂量的氟哌啶醇、氯氮平和舒必利的两种对映体也产生了明显的嗉囊反应。与右旋对映体相比，左旋舒必利更具活性。总之，目前的实验表明，与哺乳动物类似，在鸽子中抗精神病药物能够刺激催乳素分泌，并表明这些作用是通过消除紧张性多巴胺能抑制作用于下丘脑和/或垂体水平介导的。
