Selye H
Science. 1966 Jun 3;152(3727):1371-2. doi: 10.1126/science.152.3727.1371.
Subcutaneous injections of normally well tolerated amounts of hypertonic NaCl or urea solutions produce extensive topical necroses in rats systemically treated with various mast-cell dischargers and mast-cell products. This response is considered to be closely related to mitast-cell function, for it cannot be duplicated by systemic treatment with a variety of other agents.
皮下注射通常耐受性良好的高渗氯化钠或尿素溶液，会在经各种肥大细胞脱颗粒剂和肥大细胞产物全身治疗的大鼠中产生广泛的局部坏死。这种反应被认为与肥大细胞功能密切相关，因为用多种其他药物进行全身治疗无法复制这种反应。
