MacKay J S, Ross R C
Can Med Assoc J. 1966 Jun 18;94(25):1298-303.
A case of hepatoma induced by thorium dioxide (Thorotrast) is reported. The literature concerning neoplasia associated with this agent is reviewed, with emphasis on the long latent period before the development of these tumours and the equally long latent period which preceded the recognition of their iatrogenic nature.In particular, this report is intended to illustrate the diagnosis of such tumours on radiological and histological findings, provided that one is aware of their existence and familiar with the distribution and appearance of thorium dioxide deposits in the tissues. Such a diagnosis can be made without a history of thorium dioxide administration, which often may not be available.
报告了一例由二氧化钍（钍胶体）诱发的肝癌病例。对与该制剂相关的肿瘤形成的文献进行了综述，重点关注这些肿瘤发生前的漫长潜伏期以及认识到其医源性性质之前同样漫长的潜伏期。特别是，本报告旨在说明根据放射学和组织学检查结果对这类肿瘤进行诊断的情况，前提是要知晓其存在并熟悉二氧化钍在组织中的分布和表现。即使没有二氧化钍给药史（通常可能无法获取），也可作出这样的诊断。
