Gallily R, Warwick A, Bang F B
J Exp Med. 1967 Apr 1;125(4):537-48. doi: 10.1084/jem.125.4.537.
Adult or weanling C(3)H mice were found to be genetically resistant to a strain of mouse hepatitis virus. Infant C(3)H mice, however, developed infection and died from mouse hepatitis virus when minimal infectious doses of virus were given to them. There was a delay in the time of death compared to that of the genetically susceptible strain, and the virus recovered from these mice had increased pathogenicity for C(3)H mice. The ontogeny of resistance to hepatitis in the C(3)H mice thus progresses from delayed susceptibility to complete resistance as the age of the host increases. It is reflected in increased resistance of macrophages derived in vitro from liver cultures of infant mice of different ages. This increase in resistance with age was reduced by maintaining the cultures for a longer period of time before inoculation, or by increasing the number of explants in a given culture. Resistant cells were uniformly furnished by mice age 16 days, or more. It is concluded that a process of maturation of resistance of the cells takes place after the mice are born, but that this does not continue under in vitro conditions, and that it may be modified by the environment of the cells.
已发现成年或断奶的C(3)H小鼠对一种小鼠肝炎病毒株具有遗传抗性。然而，当给幼年C(3)H小鼠接种最小感染剂量的病毒时，它们会发生感染并死于小鼠肝炎病毒。与遗传易感品系相比，死亡时间有所延迟，并且从这些小鼠中分离出的病毒对C(3)H小鼠的致病性增强。因此，随着宿主年龄的增加，C(3)H小鼠对肝炎的抗性个体发育过程从延迟易感性发展到完全抗性。这体现在从不同年龄幼年小鼠肝脏培养物中体外衍生的巨噬细胞抗性增加。通过在接种前将培养物维持更长时间，或通过增加给定培养物中外植体的数量，这种随年龄增长的抗性增加会降低。16天及以上的小鼠能一致地提供抗性细胞。结论是，小鼠出生后细胞抗性会发生成熟过程，但在体外条件下这种过程不会持续，并且它可能会受到细胞环境的影响。
