大鼠脑磷脂酰肌醇激酶
The phosphatidylinositol kinase of rat brain.
作者信息
Kai M, White G L, Hawthorne J N
出版信息
Biochem J. 1966 Nov;101(2):328-37. doi: 10.1042/bj1010328.
Abstract
- The presence of a phosphatidylinositol kinase in homogenates of adult rat brain was shown by using labelled ATP or labelled phosphatidylinositol. 2. The kinase was activated by Mg(2+) or Mn(2+) and inhibited by Ca(2+), Cu(2+), K(+), Na(+) and F(-). 3. The detergents sodium deoxycholate, Cutscum and Triton X-100 markedly stimulated the reaction; sodium taurocholate, Tween-20 and cetyltrimethyl-ammonium bromide were less effective. 4. The activity of the enzyme was dependent on SH groups. 5. The subcellular distribution of the kinase in brain resembled that of Na(+)-plus-K(+)-stimulated adenosine triphosphatase and 5'-nucleotidase.
摘要
- 通过使用标记的ATP或标记的磷脂酰肌醇，证明成年大鼠脑匀浆中存在磷脂酰肌醇激酶。2. 该激酶被Mg(2+)或Mn(2+)激活，并被Ca(2+)、Cu(2+)、K(+)、Na(+)和F(-)抑制。3. 去污剂脱氧胆酸钠、Cutscum和 Triton X-100显著刺激该反应；牛磺胆酸钠、吐温-20和十六烷基三甲基溴化铵的效果较差。4. 该酶的活性依赖于SH基团。5. 脑中该激酶的亚细胞分布类似于Na(+)-K(+)-刺激的三磷酸腺苷酶和5'-核苷酸酶的分布。
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