Nb大鼠：前列腺腺癌模型。
The Nb rat: prostatic adenocarcinoma model.
作者信息
Drago J R, Ikeda R M, Maurer R E, Goldman L B, Tesluk H
出版信息
Invest Urol. 1979 Mar;16(5):353-9.
PMID:429131
Abstract
The Noble rat prostatic adenocarcinoma is an animal model which is used to study human prostatic carcinoma. It mimics the human condition in histology, in biochemistry with the production of acid phosphatase, and in tumor growth which is relatively constant. Additionally, it is hormonally dependent and metastasizes. This animal model should provide an avenue for the evaluation of cytotoxic chemotherapeutic agents heretofore receiving little attention from the urologic community.
摘要
诺布尔大鼠前列腺腺癌是一种用于研究人类前列腺癌的动物模型。它在组织学、产生酸性磷酸酶的生物化学以及相对恒定的肿瘤生长方面模拟人类情况。此外，它具有激素依赖性且会发生转移。这种动物模型应为评估迄今为止很少受到泌尿学界关注的细胞毒性化疗药物提供一条途径。
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