肾上腺素、促肾上腺皮质激素和促甲状腺激素对大鼠脂肪组织脂解作用及葡萄糖氧化的影响。
Effects of epinephrine, corticotropin, and thyrotropin on lipolysis and glucose oxidation in rat adipose tissue.
作者信息
Bray G A
出版信息
J Lipid Res. 1967 Jul;8(4):300-7.
(Log dose)-response curves have been determined for lipolysis and for the conversion of glucose-(14)C to (14)CO(2) by adipose tissue from rats in the presence of epinephrine, corticotropin, and thyrotropin. The stimulatory effect of epinephrine on lipolysis was greater than that of corticotropin or thyrotropin. Lipolysis induced by epinephrine was inhibited by propranolol but only slightly by phenoxybenzamine, whereas lipolysis induced by corticotropin was inhibited by phenoxybenzamine to a much greater extent than by propranolol. Neither blocking drug had a pronounced effect on the response to thyrotropin. Epinephrine stimulated the oxidation of glucose-(14)C to CO(2) more than did either thyrotropin or corticotropin. Moreover, epinephrine stimulated the conversion of glucose-(14)C to CO(2) and fatty acids even when lipolysis was not increased. These studies indicate that epinephrine can affect glucose utilization independently of its effect on lipolysis.
已测定了在肾上腺素、促肾上腺皮质激素和促甲状腺激素存在的情况下，大鼠脂肪组织的脂解作用以及葡萄糖 -（14）C 转化为（14）CO₂ 的（对数剂量）-反应曲线。肾上腺素对脂解的刺激作用大于促肾上腺皮质激素或促甲状腺激素。肾上腺素诱导的脂解作用被普萘洛尔抑制，但仅被酚苄明轻微抑制，而促肾上腺皮质激素诱导的脂解作用被酚苄明抑制的程度远大于被普萘洛尔抑制的程度。两种阻断药物对促甲状腺激素的反应均无明显影响。肾上腺素比促甲状腺激素或促肾上腺皮质激素更能刺激葡萄糖 -（14）C 氧化为 CO₂。此外，即使脂解作用未增强，肾上腺素也能刺激葡萄糖 -（14）C 转化为 CO₂ 和脂肪酸。这些研究表明，肾上腺素可独立于其对脂解的作用而影响葡萄糖的利用。
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