Antov G
Eksp Med Morfol. 1975;14(3):151-5.
The vascular wall is rich in glucoseaminglicanes (GAG), which form the basic intercellular substance and determine its multiple functions. Using analytic and chromatographic methods the author examined hexauronic acid (HA), pentoses (P), sulphate groups and various derivatives of GAG (hyaluronic acid (HA), pentoses (P), sulphate groups and various derivatives of GAG (hyaluronic acid (HA), dermatan-sulfate (DS), keratansulfate (KS), chondroitinsulfate (HS), and cheransulfate (HES) in human aorta, obtained from persons at the age of 10 and over 70 years of age. Ten aortas of each group were examined. The studies showed that in the aortas of the adult persons the content of HA, P, HS, KS and sulphate groups was considerably higher than that of the aourtas, obtained form the young persons. There was an impression that the adult factor affected substantialy the qualitative characteristics of GAG--with advancement of age the lenght of polysaccharide chains was shortened and the degree of sulphatation was increased. The accumulation of acid GAG in the aorta of adult persons impaired the metabolism of substances between blood and tissue, which enhanced the infiltration of the blood vessels with lipids and proteins, especialy when there was a blood increase in their content (hyperlipemia, hypercholesterinemia, ect.)
血管壁富含葡糖胺聚糖（GAG），它们构成了基本的细胞间物质并决定其多种功能。作者使用分析和色谱方法，对从10岁及70岁以上人群获取的人主动脉中的己糖醛酸（HA）、戊糖（P）、硫酸基团以及GAG的各种衍生物（透明质酸（HA）、硫酸皮肤素（DS）、硫酸角质素（KS）、硫酸软骨素（HS）和硫酸乙酰肝素（HES））进行了检测。每组检测了10条主动脉。研究表明，在成年人的主动脉中，HA、P、HS、KS和硫酸基团的含量显著高于从年轻人获取的主动脉。有一种印象是，成年因素在很大程度上影响了GAG的定性特征——随着年龄的增长，多糖链的长度缩短，硫酸化程度增加。成年人体内主动脉中酸性GAG的积累损害了血液与组织之间的物质代谢，这增强了血管对脂质和蛋白质的浸润，尤其是当它们的含量在血液中增加时（高脂血症、高胆固醇血症等） 。
