神经垂体肽与禽类血管平滑肌中镁的相互作用。
Neurohypophysial peptide interaction with magnesium in avian vascular smooth muscle.
作者信息
Somlyo A P, Somlyo A V, Woo C Y
出版信息
J Physiol. 1967 Oct;192(3):657-68. doi: 10.1113/jphysiol.1967.sp008323.
Abstract
- The contractile responses of helically cut vascular strips of chickens to vasoactive agents were studied.2. Large pulmonary arteries were contracted by neurohypophysial peptides, but not by angiotensin, acetylcholine, histamine, 5-hydroxytryptamine, bradykinin or eledoisin. The activity of oxytocin was greater than that of arginine vasopressin.3. Vasodilator effects of oxytocin upon small (200-500 mu diameter) mesenteric and muscular arteries were demonstrable, but inconsistent.4. Magnesium potentiated in a parallel fashion the vasoconstrictor effects of oxytocin and of arginine vasopressin.5. Deamino-oxytocin was potentiated by magnesium. This finding suggests a difference between the peptide-protein interactions of tissue receptors and those of neurophysin.
摘要
研究了鸡螺旋形血管条对血管活性物质的收缩反应。
神经垂体肽可使大的肺动脉收缩，但血管紧张素、乙酰胆碱、组胺、5-羟色胺、缓激肽或伊氏缩胆囊肽则无此作用。催产素的活性大于精氨酸加压素。
催产素对小的（直径200 - 500μm）肠系膜动脉和肌性动脉有舒张作用，但不稳定。
镁以平行方式增强催产素和精氨酸加压素的血管收缩作用。
脱氨基催产素被镁增强。这一发现提示组织受体的肽 - 蛋白质相互作用与神经垂体素的肽 - 蛋白质相互作用之间存在差异。
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