The syntheses and biological activities of [gly-11, 12,13]-alpha-ACTH(1-9)-nonadecapeptide, [gly-12,13] -alpha-ACTH-(1-17)-heptadecapeptide amide, [gly-11,13]-alphaACTH-(1-17)-heptadecapeptide amide, and [gly-13]-alpha-ACTH-(1-17)-heptadecapeptide amide.