Guggenheim M A, Friedman R M, Rabson A S
Science. 1968 Feb 2;159(3814):542-3. doi: 10.1126/science.159.3814.542.
In the presence of Sendai virus inactivated with ultraviolet light, nucleated chick erythrocytes can be fused with several types of human cells to form heterokaryons. Although chick erythrocytes alone cannot be stimulated by Sendai virus to produce interferon, fusion with a human cell (AH-1) which itself may produce human interferon results in heterokaryons in which the erythrocyte genome is activated and chick interferon is produced. When nucleated chick erythrocytes are fused with another type of human cell (HeLa clone S-3) which does not produce human interferon when stimulated, no chick interferon is detectable, despite morphologic changes suggestive of activation of the erythrocyte nuclei.
在紫外线灭活的仙台病毒存在的情况下，有核鸡红细胞可与多种类型的人类细胞融合形成异核体。虽然单独的鸡红细胞不能被仙台病毒刺激产生干扰素，但与自身可能产生人类干扰素的人类细胞（AH-1）融合会导致异核体形成，其中红细胞基因组被激活并产生鸡干扰素。当有核鸡红细胞与另一种在受到刺激时不产生人类干扰素的人类细胞（HeLa克隆S-3）融合时，尽管有提示红细胞核激活的形态学变化，但检测不到鸡干扰素。
