Hornnes P J, Kühl C, Lauritsen K B
J Clin Endocrinol Metab. 1979 Mar;48(3):506-8. doi: 10.1210/jcem-48-3-506.
It has been shown that the incretin effect - i.e. the gastrointestinal potentiation of the insulin response to oral glucose - is reduced in late normal pregnancy. As evidence points to gastric inhibitory polypeptide (GIP) as mediator of at least part of the incretin effect, the GIP response was determined following a 50 g oral glucose load in 6 normal women in the last trimester of pregnancy and again post partum. Compared to post partum the GIP response to oral glucose was significantly impaired in late pregnancy. It is concluded that the diminished GIP response to oral glucose in late pregnancy might at least partly explain the impaired incretin effect found in this condition.
研究表明，肠促胰岛素效应（即胃肠道对口服葡萄糖的胰岛素反应增强）在妊娠晚期正常孕妇中降低。由于有证据表明胃抑制性多肽（GIP）是肠促胰岛素效应至少部分作用的介质，因此对6名妊娠晚期正常孕妇口服50克葡萄糖后及产后的GIP反应进行了测定。与产后相比，妊娠晚期口服葡萄糖后的GIP反应明显受损。得出的结论是，妊娠晚期口服葡萄糖后GIP反应减弱可能至少部分解释了该情况下发现的肠促胰岛素效应受损。
