谷胱甘肽和巯基在鸡肝匀浆可溶性部分（105,000×g）对2,4-二氯和2,4,5-三氯苯甲酰氯的还原脱氯反应中的顺序参与。
Sequential participation of glutathione and sulph-hydryl(s) in reductive dechlorination of 2,4-di-, and 2,4,5-trichloro phenacyl chlorides by soluble fraction (105,000 x g) of chicken liver homogenate.
作者信息
Akhtar M H
出版信息
J Environ Sci Health B. 1979;14(1):53-71. doi: 10.1080/03601237909372114.
The mode of reductive dechlorination of alpha-chloroacetophenones, 2,4-di-, and 2,4,5-trichloro phenacyl chlorides into respective acetophenone by soluble fraction (105,000 x g) from chicken liver homogenate has been investigated. The transformation involved the sequential participation of glutathione and a sulph-hydryl. The phenacyl chloride first reacted with glutathione to yield the phenacyl glutathione, which in turn, in the presence of a sulph-hydryl, was reduced enzymatically to produce the ketone, probably via a disulfide intermediate.
对α-氯苯乙酮、2,4-二氯苯乙酮和2,4,5-三氯苯乙酮氯化物通过鸡肝匀浆的可溶性部分（105,000×g）还原脱氯生成各自苯乙酮的模式进行了研究。该转化过程涉及谷胱甘肽和巯基的依次参与。苯甲酰氯首先与谷胱甘肽反应生成苯甲酰谷胱甘肽，然后在巯基存在下，可能通过二硫键中间体被酶促还原生成酮。
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