Renner G, Nguyen P T
Xenobiotica. 1984 Sep;14(9):705-10. doi: 10.3109/00498258409151468.
The reductive denitration of PCNB and the reductive dechlorination of HCB are complex, and begin with reaction of both fungicides with glutathione, with elimination of the nitro group and/or of chlorine, respectively. The glutathione conjugates are further metabolized by cleavage of the glycine and glutamate residues to give cysteine conjugates or N-acetylcysteine conjugates by acetylation in mammals. The cysteine derivatives are further metabolized by cleavage of the C-S bond to produce thiophenols, which after reductive desulphuration form pentachlorobenzene, or minor chlorinated benzenes, respectively.
五氯硝基苯的还原脱硝和六氯苯的还原脱氯过程较为复杂，且均始于这两种杀菌剂与谷胱甘肽的反应，分别消除硝基和/或氯。谷胱甘肽共轭物在哺乳动物体内通过甘氨酸和谷氨酸残基的裂解进一步代谢，通过乙酰化生成半胱氨酸共轭物或N - 乙酰半胱氨酸共轭物。半胱氨酸衍生物通过C - S键的裂解进一步代谢生成苯硫酚，苯硫酚经过还原脱硫分别形成五氯苯或少量氯代苯。
